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This content will become publicly available on July 1, 2025

Title: Cross-correlation image analysis for real-time single particle tracking

Accurately measuring the translations of objects between images is essential in many fields, including biology, medicine, chemistry, and physics. One important application is tracking one or more particles by measuring their apparent displacements in a series of images. Popular methods, such as the center of mass, often require idealized scenarios to reach the shot noise limit of particle tracking and, therefore, are not generally applicable to multiple image types. More general methods, such as maximum likelihood estimation, reliably approach the shot noise limit, but are too computationally intense for use in real-time applications. These limitations are significant, as real-time, shot-noise-limited particle tracking is of paramount importance for feedback control systems. To fill this gap, we introduce a new cross-correlation-based algorithm that approaches shot-noise-limited displacement detection and a graphics processing unit-based implementation for real-time image analysis of a single particle.

 
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Award ID(s):
2227079 2011783
PAR ID:
10528732
Author(s) / Creator(s):
; ; ; ; ; ; ; ;
Publisher / Repository:
Review of Scientific Instruments
Date Published:
Journal Name:
Review of Scientific Instruments
Volume:
95
Issue:
7
ISSN:
0034-6748
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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