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The fast, accurate detection of biomolecules, ranging from nucleic acids and small molecules to proteins and cellular secretions, plays an essential role in various biomedical applications. These include disease diagnostics and prognostics, environmental monitoring, public health, and food safety. Aptamer recognition (DNA or RNA) has gained extensive attention for biomolecular detection due to its high selectivity, affinity, reproducibility, and robustness. Concurrently, biosensing with nanoparticles has been widely used for its high carrier capacity, stability and feasibility of incorporating optical and catalytic activity, and enhanced diffusivity. Biosensors based on aptamers and nanoparticles utilize the combination of their advantages and have become a promising technology for detecting of a wide variety of biomolecules with high sensitivity, reliability, specificity, and detection speed. Via various sensing mechanisms, target biomolecules have been quantified in terms of optical (e.g., colorimetric and fluorometric), magnetic, and electrical signals. In this review, we summarize the recent advances in and compare different aptamer–nanoparticle-based biosensors by nanoparticle types and detection mechanisms. We also share our views on the highlights and challenges of the different nanoparticle-aptamer-based biosensors.
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Advances in Plasmonic Photonic Crystal Fiber Biosensors: Exploring Innovative Materials for Bioimaging and Environmental Monitoring
Abstract This review paper comprehensively analyzes recent advancements in optical fiber‐based biosensors, focusing on conventional fiber and photonic crystal structures. This paper overviews the significant applications of optical fiber biosensors, including bioimaging, quality analysis, food safety, and field environment monitoring, setting the stage for subsequent discussions. The primary objective of the review is to systematically evaluate recent literature concerning optical fiber‐based biosensors, emphasizing their sensitivities and resolutions. The second section explores integrating plasmonic materials such as graphene, TDMC, germanium, black phosphorus, and silicon within optical fiber biosensors, elucidating their roles in enhancing sensitivity and resolution in biosensing applications. A detailed examination of photonic crystal fibers (PCF) follows, categorizing them into internally and externally metal film‐coated biosensors, highlighting their distinct advantages and limitations. Comparative analyses in two tables delineate the performance and sensitivity of optical fiber‐based biosensors, mainly focusing on different coating strategies. The final section of the review discusses emerging trends and applications in optical fiber biosensing technologies, underscoring their potential to transform biomedical and environmental monitoring fields. By synthesizing recent developments and challenges, this review aims to offer researchers and practitioners a comprehensive understanding of optical fiber‐based biosensors, facilitating informed decision‐making and driving further advancements in the field.
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- Award ID(s):
- 2344476
- PAR ID:
- 10560622
- Publisher / Repository:
- Wiley-VCH GmbH
- Date Published:
- Journal Name:
- ChemistrySelect
- Volume:
- 9
- Issue:
- 28
- ISSN:
- 2365-6549
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1002/slct.202401265
