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Abstract MOV10 is an RNA helicase that associates with the RNA‐induced silencing complex component Argonaute (AGO), likely resolving RNA secondary structures. MOV10 also binds the Fragile X mental retardation protein to block AGO2 binding at some sites and associates with UPF1, a principal component of the nonsense‐mediated RNA decay pathway. MOV10 is widely expressed and has a key role in the cellular response to viral infection and in suppressing retrotransposition. Posttranslational modifications of MOV10 include ubiquitination, which leads to stimulation‐dependent degradation, and phosphorylation, which has an unknown function. MOV10 localizes to the nucleus and/or cytoplasm in a cell type‐specific and developmental stage‐specific manner. Knockout ofMov10leads to embryonic lethality, underscoring an important role in development where it is required for the completion of gastrulation. MOV10 is expressed throughout the organism; however, most studies have focused on germline cells and neurons. In the testes, the knockdown ofMov10disrupts proliferation of spermatogonial progenitor cells. In brain, MOV10 is significantly elevated postnatally and binds mRNAs encoding cytoskeleton and neuron projection proteins, suggesting an important role in neuronal architecture. HeterozygousMov10mutant mice are hyperactive and anxious and their cultured hippocampal neurons have reduced dendritic arborization. Zygotic knockdown ofMov10inXenopus laeviscauses abnormal head and eye development and mislocalization of neuronal precursors in the brain. Thus, MOV10 plays a vital role during development, defense against viral infection and in neuronal development and function: its many roles and regulation are only beginning to be unraveled. This article is categorized under:RNA Interactions with Proteins and Other Molecules > RNA‐Protein ComplexesRNA Interactions with Proteins and Other Molecules > Protein‐RNA Interactions: Functional Implications
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This content will become publicly available on January 17, 2026
Evolving mineralogy and reactivity of hematite-coated sands during reduction of 4-chloronitrobenzene by Fe( ii ) in flow-through reactors
Reaction of a model nitroaromatic pollutant with hematite-coated sand in column reactors leads to growth of goethite and evolving reactivity due to changes in accessible surface area.
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- PAR ID:
- 10570665
- Publisher / Repository:
- Royal Society of Chemistry
- Date Published:
- Journal Name:
- Environmental Science: Nano
- Volume:
- 12
- Issue:
- 1
- ISSN:
- 2051-8153
- Page Range / eLocation ID:
- 514 to 527
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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