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This content will become publicly available on November 12, 2025

Title: Scale invariance in early embryonic development
The expression of a few key genes determines the body plan of the fruit fly. We show that the spatial expression patterns for several of these genes scale precisely with embryo size. Discrete positional markers such as the peaks in striped patterns or the boundaries of expression domains have positions along the embryo’s major axis proportional to embryo length, accurate to within 1%. Further, the information (in bits) that graded patterns of expression provide about a cell’s position can be decomposed into information about fractional or scaled position and information about absolute position or embryo length; all information available is about scaled position, with < 2% error. These findings imply that the underlying genetic network’s behavior exhibits scale invariance in a more precise mathematical sense. We argue that models that can explain this scale invariance also have a “zero mode” in the dynamics of gene expression, and this connects to observations on the spatial correlation of fluctuations in expression levels.  more » « less
Award ID(s):
1734030
PAR ID:
10572789
Author(s) / Creator(s):
; ; ; ; ; ; ; ;
Publisher / Repository:
arXiv
Date Published:
Journal Name:
Proceedings of the National Academy of Sciences
Volume:
121
Issue:
46
ISSN:
0027-8424
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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