An official website of the United States government
Abstract The variability of the Hadley circulation strength (HCS), crucial to tropical climate variability, is attributed to both oceanic and atmospheric forcings. El Niño–Southern Oscillation (ENSO) and variations in the extratropical upper-tropospheric eddies are the known drivers of the interannual HCS variability. However, the relative contributions of these oceanic and atmospheric forcings to the hemispheric HCS variability are not well understood. In particular, how much anomalous wind stress–driven ocean dynamics, including ENSO, impact HCS variability remains an open question. To address these gaps, we investigate the drivers of the interannual HCS variability using global coupled model experiments that include or exclude anomalous wind stress–driven ocean circulation variability. We find that the anomalous wind stress–driven ocean circulation variability significantly amplifies HCS variability in the Southern Hemisphere (SH). ENSO is the leading modulator of the SH HCS variability, which offers the potential to improve the predictability of Hadley circulation (HC)–related hydrological consequences. On the other hand, the Northern Hemisphere (NH) HCS variability is predominantly influenced by the eddy-driven internal atmospheric variability with little role in ocean dynamics. We hypothesize that the large eddy variability in the NH and concentrated ENSO-associated heating and precipitation in the SH lead to the hemisphere-dependent differences in the interannual HCS variability.
more »
« less
The role of conventional and unconventional adaptive routes in lowering of intraocular pressure: Theoretical model and simulation
In this article, we propose a theoretical model leveraging the analogy between fluid and electric variables to investigate the relation among aqueous humor (AH) circulation and drainage and intraocular pressure (IOP), the principal established risk factor of severe neuropathologies of the optic nerve such as glaucoma. IOP is the steady-state result of the balance among AH secretion (AHs), circulation (AHc), and drainage (AHd). AHs are modeled as a given volumetric flow rate electrically corresponding to an input current source. AHc is modeled by the series of two linear hydraulic conductances (HCs) representing the posterior and anterior chambers. AHd is modeled by the parallel of three HCs: a linear HC for the conventional adaptive route (ConvAR), a nonlinear HC for the hydraulic component of the unconventional adaptive route (UncAR), and a nonlinear HC for the drug-dependent component of the UncAR. The proposed model is implemented in a computational virtual laboratory to study the value attained by the IOP under physiological and pathological conditions. Simulation results (i) confirm the conjecture that the UncAR acts as a relief valve under pathological conditions, (ii) indicate that the drug-dependent AR is the major opponent to IOP increase in the case of elevated trabecular meshwork resistance, and (iii) support the use of the model as a quantitative tool to complement in vivo studies and help design and optimize medications for ocular diseases.
more »
« less
- PAR ID:
- 10589121
- Publisher / Repository:
- American Institute of Physics
- Date Published:
- Journal Name:
- Physics of Fluids
- Volume:
- 35
- Issue:
- 6
- ISSN:
- 1070-6631
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
More Like this
-
-
Real-time hybrid simulation (RTHS) divides a structural system into analytical and experimental substructures that are coupled through their common degrees of freedom. This paper introduces a framework to enable RTHS to be performed on 3D nonlinear models of tall buildings with rate dependent nonlinear response modification devices, where the structure is subjected to multi-directional wind and earthquake natural hazards. A 40-story tall building prototype with damped outriggers is selected as a case study. The analytical substructure for the RTHS consists of a 3-D nonlinear model of the structure, where each member in the building is discretely modeled in conjunction with the use of a super element. The experimental substructure for the RTHS consists of a full-scale rate-dependent nonlinear viscous damper that is physically tested in the lab, with the remaining dampers in the outrigger system modeled analytically. The analytically modeled dampers use a stable explicit non-iterative element with an online model updating algorithm, by which the covariance matrix of the damper model’s state variables does not become ill-conditioned. The damper model parameters can thereby be updated in real-time using measured data from the experimental substructure. The explicit MKR-α method is optimized and used in conjunction with the super element to efficiently integrate the condensed equations of motion of a large complex model having more than 1000 nonlinear elements, thus enabling multi-axis earthquake and wind hybrid nonlinear simulations to be performed in real-time. An adaptive servo-hydraulic actuator control scheme is used to enable precise real-time actuator displacements in the experimental substructure to be achieved that match the target displacements during a RTHS. The IT real-time architecture for integrating the components of the framework is described. To assess the framework, 3D RTHS of the 40-story structure were performed involving multi-axis translational and torsional response to multi-directional earthquake and wind natural hazards. The RTHS technique was applied to perform half-power tests to experimentally determine the amount of supplemental damping provided by the damped outrigger system for translational and torsional modes of vibration of the building. The results from the study presented herein demonstrate that RTHS can be applied to large nonlinear large structural systems involving multi-axis response to multi-directional excitation.more » « less
-
Abstract Recent studies have shown a large spread in the transport of atmospheric tracers into the Arctic among a suite of chemistry climate models and have suggested that this is related to the spread in the meridional extent of the Hadley Cell (HC). Here we examine the HC‐transport relationship using an idealized model, where we vary the mean circulation and isolate its impact on transport to the Arctic. It is shown that the poleward transport depends on the relative position between the northern edge of the HC and the tracer source, with maximum transport occurring when the HC edge lies near the middle of the source region. Such dependence highlights the critical role of near‐surface transport by the Eulerian mean circulation rather than eddy mixing in the free troposphere and suggests that variations in the HC edge and the tracer source region are both important for modeling Arctic composition.more » « less
-
null (Ed.)The role of the cannabinoid receptor 2 (CNR2) is still poorly described in sensory epithelia. We found strong cnr2 expression in hair cells (HCs) of the inner ear and the lateral line (LL), a superficial sensory structure in fish. Next, we demonstrated that sensory synapses in HCs were severely perturbed in larvae lacking cnr2. Appearance and distribution of presynaptic ribbons and calcium channels (Ca v 1.3) were profoundly altered in mutant animals. Clustering of membrane-associated guanylate kinase (MAGUK) in post-synaptic densities (PSDs) was also heavily affected, suggesting a role for cnr2 for maintaining the sensory synapse. Furthermore, vesicular trafficking in HCs was strongly perturbed suggesting a retrograde action of the endocannabinoid system (ECs) via cnr2 that was modulating HC mechanotransduction. We found similar perturbations in retinal ribbon synapses. Finally, we showed that larval swimming behaviors after sound and light stimulations were significantly different in mutant animals. Thus, we propose that cnr2 is critical for the processing of sensory information in the developing larva.more » « less
-
Abstract This study investigated how ocean optical properties and solar attenuation may affect the upper ocean temperature structure and ocean heat content (OHC). We employed a realistic three‐dimensional ocean circulation model for the northwestern Atlantic to simulate ocean states during the active Atlantic hurricane season of 2017. Sensitivity experiments were performed by coupling the ocean circulation prediction with either a conventional water type‐based solar attenuation model or an inherent optical properties (IOP)‐based model. Validations against in‐situ ocean temperature observations and remote sensing‐derived OHC showed that ocean simulations using the IOP‐based model outperformed simulations using the conventional water type‐based model in predicting sea surface temperature, upper ocean thermal structure, and OHC. An OHC‐hurricane intensity relationship derived for five major hurricanes in 2017 suggests that the ocean optical properties and the application of an appropriate solar attenuation model are important for the forecast of hurricane intensity.more » « less
