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In 2013, the United Nations Food and Agriculture Organization identified insects as a promising solution for sustainably feeding the world’s growing population. However, despite a decade of development and innovation, the insect industry has yet to fully realize its environmental and economic potential. This review takes an evidence-based approach to addressing key challenges in the sector, including integrating circular production systems within existing regulatory frameworks in the Global North, ensuring product safety in circular systems, assessing allergen risks associated with insect-based products, mitigating biosecurity risks linked to non-native insect species, evaluating the environmental safety of insect by-products, and promoting animal welfare in insect production. While significant challenges remain, the evidence presented highlights how further research can help unlock opportunities for the industry to achieve its full potential globally. Ultimately, we argue that overcoming challenges – ‘working out the bugs’ – is a fundamental step in the evolution of any emerging industry. Furthermore, greater support for the transition to circular economies will accelerate the sector’s ability to generate meaningful environmental, ethical, and economic benefits. 

CryoDRGN is a machine learning system for heterogenous cryo-EM reconstruction of proteins and protein complexes from single particle cryo-EM data. Central to this approach is a deep generative model for heterogeneous cryo-EM density maps, which we empirically find effectively models both discrete and continuous forms of structural variability. Once trained, cryoDRGN is capable of generating an arbitrary number of 3D density maps, and thus interpreting the resulting ensemble is a challenge. Here, we showcase interactive and automated processing approaches for analyzing cryoDRGN results. Specifically, we detail a step-by-step protocol for analysis of the assembling 50S ribosome dataset (Davis et al., EMPIAR-10076), including preparation of inputs, network training, and visualization of the resulting ensemble of density maps. Additionally, we describe and implement methods to comprehensively analyze and interpret the distribution of volumes with the assistance of an associated atomic model. This protocol is appropriate for structural biologists familiar with processing single particle cryo-EM datasets and with moderate experience navigating Python and Jupyter notebooks. It requires 3-4 days to complete. 

We present a measurement of the branching fraction and fraction of longitudinal polarization of $B^0\to {\rho }^{+}{\rho }^{-}$decays, which have two ${\pi }^0$’s in the final state. We also measure time-dependent $CP$violation parameters for decays into longitudinally polarized ${\rho }^{+}{\rho }^{-}$pairs. This analysis is based on a data sample containing $(387\pm 6)\times {10}^6$ $\mathrm{\Upsilon }\left(4S\right)$mesons collected with the Belle II detector at the SuperKEKB asymmetric-energy $e^{+}{e}^{-}$collider in 2019–2022. We obtain $\mathcal{B}(B^0\to {\rho }^{+}{\rho }^{-})=\left(2.89_{-0.22}^{+0.23}{}_{-0.27}^{+0.29}\right)\times {10}^{-5}$, $f_L=0.921_{-0.025}^{+0.024}{}_{-0.015}^{+0.017}$, $S=-0.26\pm 0.19\pm 0.08$, and $C=-0.02\pm 0.12_{-0.05}^{+0.06}$, where the first uncertainties are statistical and the second are systematic. We use these results to perform an isospin analysis to constrain the Cabibbo-Kobayashi-Maskawa angle ${\varphi }_2$and obtain two solutions; the result consistent with other Standard Model constraints is ${\varphi }_2=\left({92.6}_{-4.7}^{+4.5}\right)°$. Published by the American Physical Society2025 

A<sc>bstract</sc> Using data samples of 983.0 fb⁻¹and 427.9 fb⁻¹accumulated with the Belle and Belle II detectors operating at the KEKB and SuperKEKB asymmetric-energye⁺e⁻colliders, singly Cabibbo-suppressed decays$$ {\Xi}_c^{+}\to p{K}_S^0 $$ ${\Xi }_c^{+}\to p{K}_S^0$,$$ {\Xi}_c^{+}\to \Lambda {\pi}^{+} $$ ${\Xi }_c^{+}\to \Lambda {\pi }^{+}$, and$$ {\Xi}_c^{+}\to {\Sigma}^0{\pi}^{+} $$ ${\Xi }_c^{+}\to {\Sigma }^0{\pi }^{+}$are observed for the first time. The ratios of branching fractions of$$ {\Xi}_c^{+}\to p{K}_S^0 $$ ${\Xi }_c^{+}\to p{K}_S^0$,$$ {\Xi}_c^{+}\to \Lambda {\pi}^{+} $$ ${\Xi }_c^{+}\to \Lambda {\pi }^{+}$, and$$ {\Xi}_c^{+}\to {\Sigma}^0{\pi}^{+} $$ ${\Xi }_c^{+}\to {\Sigma }^0{\pi }^{+}$relative to that of$$ {\Xi}_c^{+}\to {\Xi}^{-}{\pi}^{+}{\pi}^{+} $$ ${\Xi }_c^{+}\to {\Xi }^{-}{\pi }^{+}{\pi }^{+}$are measured to be$$ {\displaystyle \begin{array}{c}\frac{\mathcal{B}\left({\Xi}_c^{+}\to p{K}_S^0\right)}{\mathcal{B}\left({\Xi}_c^{+}\to {\Xi}^{-}{\pi}^{+}{\pi}^{+}\right)}=\left(2.47\pm 0.16\pm 0.07\right)\%,\\ {}\frac{\mathcal{B}\left({\Xi}_c^{+}\to \Lambda {\pi}^{+}\right)}{\mathcal{B}\left({\Xi}_c^{+}\to {\Xi}^{-}{\pi}^{+}{\pi}^{+}\right)}=\left(1.56\pm 0.14\pm 0.09\right)\%,\\ {}\frac{\mathcal{B}\left({\Xi}_c^{+}\to {\Sigma}^0{\pi}^{+}\right)}{\mathcal{B}\left({\Xi}_c^{+}\to {\Xi}^{-}{\pi}^{+}{\pi}^{+}\right)}=\left(4.13\pm 0.26\pm 0.22\right)\%.\end{array}} $$ $\begin{array}{c}\frac{B\left({\Xi }_c^{+}\to p{K}_S^0\right)}{B\left({\Xi }_c^{+}\to {\Xi }^{-}{\pi }^{+}{\pi }^{+}\right)}=\left(2.47\pm 0.16\pm 0.07\right)\%,\\ \frac{B\left({\Xi }_c^{+}\to \Lambda {\pi }^{+}\right)}{B\left({\Xi }_c^{+}\to {\Xi }^{-}{\pi }^{+}{\pi }^{+}\right)}=\left(1.56\pm 0.14\pm 0.09\right)\%,\\ \frac{B\left({\Xi }_c^{+}\to {\Sigma }^0{\pi }^{+}\right)}{B\left({\Xi }_c^{+}\to {\Xi }^{-}{\pi }^{+}{\pi }^{+}\right)}=\left(4.13\pm 0.26\pm 0.22\right)\%.\end{array}$ Multiplying these values by the branching fraction of the normalization channel,$$ \mathcal{B}\left({\Xi}_c^{+}\to {\Xi}^{-}{\pi}^{+}{\pi}^{+}\right)=\left(2.9\pm 1.3\right)\% $$ $B\left({\Xi }_c^{+}\to {\Xi }^{-}{\pi }^{+}{\pi }^{+}\right)=\left(2.9\pm 1.3\right)\%$, the absolute branching fractions are determined to be$$ {\displaystyle \begin{array}{c}\mathcal{B}\left({\Xi}_c^{+}\to p{K}_S^0\right)=\left(7.16\pm 0.46\pm 0.20\pm 3.21\right)\times {10}^{-4},\\ {}\mathcal{B}\left({\Xi}_c^{+}\to \Lambda {\pi}^{+}\right)=\left(4.52\pm 0.41\pm 0.26\pm 2.03\right)\times {10}^{-4},\\ {}\mathcal{B}\left({\Xi}_c^{+}\to {\Sigma}^0{\pi}^{+}\right)=\left(1.20\pm 0.08\pm 0.07\pm 0.54\right)\times {10}^{-3}.\end{array}} $$ $\begin{array}{c}B\left({\Xi }_c^{+}\to p{K}_S^0\right)=\left(7.16\pm 0.46\pm 0.20\pm 3.21\right)\times {10}^{-4},\\ B\left({\Xi }_c^{+}\to \Lambda {\pi }^{+}\right)=\left(4.52\pm 0.41\pm 0.26\pm 2.03\right)\times {10}^{-4},\\ B\left({\Xi }_c^{+}\to {\Sigma }^0{\pi }^{+}\right)=\left(1.20\pm 0.08\pm 0.07\pm 0.54\right)\times {10}^{-3}.\end{array}$ The first and second uncertainties above are statistical and systematic, respectively, while the third ones arise from the uncertainty in$$ \mathcal{B}\left({\Xi}_c^{+}\to {\Xi}^{-}{\pi}^{+}{\pi}^{+}\right) $$ $B\left({\Xi }_c^{+}\to {\Xi }^{-}{\pi }^{+}{\pi }^{+}\right)$. 

We measure the branching fraction and $CP$-violating flavor-dependent rate asymmetry of $B^0\to {\pi }^0{\pi }^0$decays reconstructed using the Belle II detector in an electron-positron collision sample containing $387\times {10}^6\mathrm{\Upsilon }\left(4S\right)$mesons. Using an optimized event selection, we find $125\pm 20$signal decays in a fit to background-discriminating and flavor-sensitive distributions. The resulting branching fraction is $(1.25\pm 0.23)\times {10}^{-6}$and the $CP$-violating asymmetry is $0.03\pm 0.30$. Published by the American Physical Society2025 

A<sc>bstract</sc> We report measurements of the absolute branching fractions$$\mathcal{B}\left({B}_{s}^{0}\to {D}_{s}^{\pm }X\right)$$,$$\mathcal{B}\left({B}_{s}^{0}\to {D}^{0}/{\overline{D} }^{0}X\right)$$, and$$\mathcal{B}\left({B}_{s}^{0}\to {D}^{\pm }X\right)$$, where the latter is measured for the first time. The results are based on a 121.4 fb⁻¹data sample collected at the Υ(10860) resonance by the Belle detector at the KEKB asymmetric-energye⁺e⁻collider. We reconstruct one$${B}_{s}^{0}$$meson in$${e}^{+}{e}^{-}\to \Upsilon\left(10860\right)\to {B}_{s}^{*}{\overline{B} }_{s}^{*}$$events and measure yields of$${D}_{s}^{+}$$,D⁰, andD⁺mesons in the rest of the event. We obtain$$\mathcal{B}\left({B}_{s}^{0}\to {D}_{s}^{\pm }X\right)=\left(68.6\pm 7.2\pm 4.0\right)\%$$,$$\mathcal{B}\left({B}_{s}^{0}\to {D}^{0}/{\overline{D} }^{0}X\right)=\left(21.5\pm 6.1\pm 1.8\right)\%$$, and$$\mathcal{B}\left({B}_{s}^{0}\to {D}^{\pm }X\right)=\left(12.6\pm 4.6\pm 1.3\right)\%$$, where the first uncertainty is statistical and the second is systematic. Averaging with previous Belle measurements gives$$\mathcal{B}\left({B}_{s}^{0}\to {D}_{s}^{\pm }X\right)=\left(63.4\pm 4.5\pm 2.2\right)\%$$and$$\mathcal{B}\left({B}_{s}^{0}\to {D}^{0}/{\overline{D} }^{0}X\right)=\left(23.9\pm 4.1\pm 1.8\right)\%$$. For the$${B}_{s}^{0}$$production fraction at the Υ(10860), we find$${f}_{s}=\left({21.4}_{-1.7}^{+1.5}\right)\%$$. 

We measure the branching fraction of the decay $B^0\to J/\psi \omega$using data collected with the Belle II detector at the SuperKEKB collider. The data contain $(387\pm 6)\times {10}^{6}B\overline{B}$meson pairs produced in energy-asymmetric $e^{+}{e}^{-}$collisions at the $\mathrm{\Upsilon }\left(4S\right)$resonance. The measured branching fraction $\mathcal{B}(B^0\to J/\psi \omega )=(2.16\pm 0.30\pm 0.14)\times {10}^{-5}$, where the first uncertainty is statistical and the second is systematic, is more precise than previous results and constitutes the first observation of the decay with a significance of 6.5 standard deviations. Published by the American Physical Society2025 

We measure the time-integrated $CP$asymmetry in $D^0\to K_S^0{K}_S^0$decays reconstructed in $e^{+}{e}^{-}\to c\overline{c}$events collected by the Belle and Belle II experiments. The corresponding data samples have integrated luminosities of 980 and $428{\mathrm{fb}}^{-1}$, respectively. The $D^0$decays are required to originate from the $D^{*+}\to D^0{\pi }^{+}$decay, which determines the charm flavor at production time. A control sample of $D^0\to K^{+}{K}^{-}$decays is used to correct for production and detection asymmetries. The result, $(-1.4\pm 1.3\left(\mathrm{stat}\right)\pm 0.1\left(\mathrm{syst}\right))\%$, is consistent with previous determinations and with $CP$symmetry. Published by the American Physical Society2025