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Context. Direct observations of exoplanet and brown dwarf companions with near-infrared interferometry, first enabled by the dualfield mode of VLTI/GRAVITY, provide unique measurements of the objects’ orbital motions and atmospheric compositions. Aims. Here we compile a homogeneous library of all exoplanet and brown dwarfK-band spectra observed by GRAVITY thus far. This ExoGRAVITY Spectral Library is made publicly available online. Methods. We re-reduced all the available GRAVITY dual-field high-contrast data in a uniform and highly automated way and, where companions were detected, extracted their ~2.0-2.4 μmK-band contrast spectra. We then derived stellar model atmospheres for all the employed flux references (either the host star or the swap calibrator), which we used to convert the companion contrast into companion flux spectra. Solely from the resulting GRAVITYK-band flux spectra, we extracted spectral types, spectral indices, and bulk physical properties for all the companions. Finally, and with the help of age constraints from the literature, we also derived isochronal masses for most of the companions using evolutionary models. Results. The resulting library containsR~ 500 GRAVITYK-band spectra of 39 substellar companions from late M to late T spectral types, including the entire L-T transition. Throughout this transition, a shift from CO-dominated late M- and L-type dwarfs to CH₄-dominated T-type dwarfs can be observed in theK-band. The GRAVITY spectra alone constrain the objects’ bolometric luminosity to typically within ±0.15 dex. The derived isochronal masses agree with dynamical masses from the literature where available, except for HD 4113 c for which we confirm its previously reported potential underluminosity. Conclusions. Medium-resolution spectroscopy of substellar companions with GRAVITY provides insight into the carbon chemistry and the cloudiness of these objects’ atmospheres. It also constrains these objects’ bolometric luminosities, which can yield measurements of their formation entropy if combined with dynamical masses, for instance from Gaia and GRAVITY astrometry. 

We present the measurement of ${\pi }^{+}$-argon inelastic cross sections using the ProtoDUNE single-phase liquid argon time projection chamber in the incident ${\pi }^{+}$kinetic energy range of 500–800 MeV in multiple exclusive channels (absorption, charge exchange, and the remaining inelastic interactions). The results of this analysis are important inputs to simulations of liquid argon neutrino experiments such as the Deep Underground Neutrino Experiment and the Short Baseline Neutrino program at Fermi National Accelerator Laboratory. They will be employed to improve the modeling of final state interactions within neutrino event generators used by these experiments, as well as the modeling of ${\pi }^{+}$-argon secondary interactions within the liquid argon. This is the first measurement of ${\pi }^{+}$-argon absorption at this kinetic energy range as well as the first ever measurement of ${\pi }^{+}$-argon charge exchange. 

Context. A low-mass companion potentially in the brown dwarf mass regime was discovered on a ~12 yr orbit (~5.5 au) around HD 167665 using radial velocity (RV) monitoring. Joint RV–astrometry analyses confirmed that HD 167665B is a brown dwarf with precisions on the measured mass of ~4–9%. Brown dwarf companions with measured mass and luminosity are valuable for testing formation and evolutionary models. However, its atmospheric properties and luminosity are still unconstrained, preventing detailed tests of evolutionary models. Aims. We further characterize the HD 167665 system by measuring the luminosity and refining the mass of its companion and reassessing the stellar age. Methods. We present new high-contrast imaging data of the star and of its close-in environment from SPHERE and GRAVITY, which we combined with RV data from CORALIE and HIRES and astrometry from HIPPARCOSandGaia. Results. The analysis of the host star properties indicates an age of 6.20 ± 1.13 Gyr. GRAVITY reveals a point source near the position predicted from a joint fit of RV data and HIPPARCOS–Gaiaproper motion anomalies. Subsequent SPHERE imaging confirms the detection and reveals a faint point source of contrast of ∆H2= 10.95 ± 0.33 mag at a projected angular separation of ~180 mas. A joint fit of the high-contrast imaging, RV, and HIPPARCOSintermediate astrometric data together with theGaiaastrometric parameters constrains the mass of HD 167665B to ~1.2%, 60.3 ± 0.7M_J. The SPHERE colors and spectrum point to an early or mid-T brown dwarf of spectral type T4₋₂⁺¹. Fitting the SPHERE spectrophotometry and GRAVITY spectrum with synthetic spectra suggests an effective temperature of ~1000–1150 K, a surface gravity of ~5.0–5.4 dex, and a bolometric luminosity log(L/L_⊙)=−4.892_−0.028^+0.024dex. The mass, luminosity, and age of the companion can only be reproduced within 3σby the hybrid cloudy evolutionary models of Saumon & Marley (2008, ApJ, 689, 1327), whereas cloudless evolutionary models underpredict its luminosity. 

The Deep Underground Neutrino Experiment (DUNE) is a next-generation neutrino experiment with a rich physics program that includes searches for the hypothetical phenomenon of proton decay. Utilizing liquid-argon time-projection chamber technology, DUNE is expected to achieve world-leading sensitivity in the proton decay channels that involve charged kaons in their final states. The first DUNE demonstrator, ProtoDUNE Single-Phase, was a 0.77 kt detector that operated from 2018 to 2020 at the CERN Neutrino Platform, exposed to a mixed hadron and electron test-beam with momenta ranging from 0.3 to $7\mathrm{GeV}/\mathrm{c}$. We present a selection of low-energy kaons among the secondary particles produced in hadronic reactions, using data from the 6 and $7\mathrm{GeV}/\mathrm{c}$beam runs. The selection efficiency is 1% and the sample purity 92%. The initial energies of the selected kaon candidates encompass the expected energy range of kaons originating from proton decay events in DUNE (below $\sim 200\mathrm{MeV}$). In addition, we demonstrate the capability of this detector technology to discriminate between kaons and other particles such as protons and muons, and provide a comprehensive description of their energy loss in liquid argon, which shows good agreement with the simulation. These results pave the way for future proton decay searches at DUNE. 

The 2x2 Demonstrator, a prototype for the Deep Underground Neutrino Experiment (DUNE) liquid argon (LAr) Near Detector, was exposed to the Neutrinos from the Main Injector (NuMI) neutrino beam at Fermi National Accelerator Laboratory (Fermilab). This detector is a prototype of a new modular design for a liquid argon time-projection chamber (LArTPC), comprising a two-by-two array of four modules, each further segmented into two optically isolated LArTPCs. The 2x2 Demonstrator features a number of pioneering technologies, including a low-profile resistive field shell to establish drift fields, native 3D ionization pixelated imaging, and a high-coverage dielectric light readout system. The 2.4-tonne active mass detector is flanked upstream and downstream by supplemental solid-scintillator tracking planes, repurposed from the MINERvA experiment, which track ionizing particles exiting the argon volume. The antineutrino beam data collected by the detector over a 4.5 day period in 2024 include over 30,000 neutrino interactions in the LAr active volume—the first neutrino interactions reported by a DUNE detector prototype. During its physics-quality run, the 2x2 Demonstrator operated at a nominal drift field of 500 V/cm and maintained good LAr purity, with a stable electron lifetime of approximately 1.25 ms. This paper describes the detector and supporting systems, summarizes the installation and commissioning, and presents the initial validation of collected NuMI beam and off-beam self-triggers. In addition, it highlights observed interactions in the detector volume, including candidate muon antineutrino events. 

We present a search for long-lived particles (LLPs), produced in kaon decays, that decay to two muons inside the ICARUS neutrino detector. This channel would be a signal of hidden sector models that can address outstanding issues in particle physics such as the strong CP problem and the microphysical origin of dark matter. The search is performed with data collected in the Neutrinos at the Main Injector (NuMI) beam at Fermilab corresponding to $2.41\times {10}^{20}$protons-on-target. No new physics signal is observed, and we set world leading limits on heavy QCD axions, as well as for the Higgs portal scalar among dedicated searches. Limits are also presented in a model-independent way applicable to any new physics model predicting the process $K\to \pi +S(\to \mu \mu )$, for a LLP $S$. This result is the first search for new physics performed with the ICARUS detector at Fermilab. It paves the way for the future program of LLP searches at ICARUS. Published by the American Physical Society2025 

Existing three-dimensional (3D) culture techniques are limited by trade-offs between throughput, capacity for high-resolution imaging in living state, and geometric control. Here, we introduce a modular microscale hanging drop culture where simple design elements allow high replicates for drug screening, direct on-chip real-time or high-resolution confocal microscopy, and geometric control in 3D. Thousands of spheroids can be formed on our microchip in a single step and without any selective pressure from specific matrices. Microchip cultures from human LN229 glioblastoma and patient-derived mouse xenograft cells retained genomic alterations of originating tumors based on mate pair sequencing. We measured response to drugs over time with real-time microscopy on-chip. Last, by engineering droplets to form predetermined geometric shapes, we were able to manipulate the geometry of cultured cell masses. These outcomes can enable broad applications in advancing personalized medicine for cancer and drug discovery, tissue engineering, and stem cell research. 

Abstract This paper reports on a measurement of electron-ion recombination in liquid argon in the ICARUS liquid argon time projection chamber (LArTPC). A clear dependence of recombination on the angle of the ionizing particle track relative to the drift electric field is observed. An ellipsoid modified box (EMB) model of recombination describes the data across all measured angles. These measurements are used for the calorimetric energy scale calibration of the ICARUS TPC, which is also presented. The impact of the EMB model is studied on calorimetric particle identification, as well as muon and proton energy measurements. Accounting for the angular dependence in EMB recombination improves the accuracy and precision of these measurements. 

Abstract The ICARUS liquid argon time projection chamber (LArTPC) neutrino detector has been taking physics data since 2022 as part of the Short-Baseline Neutrino (SBN) Program. This paper details the equalization of the response to charge in the ICARUS time projection chamber (TPC), as well as data-driven tuning of the simulation of ionization charge signals and electronics noise. The equalization procedure removes non-uniformities in the ICARUS TPC response to charge in space and time. This work leverages the copious number of cosmic ray muons available to ICARUS at the surface. The ionization signal shape simulation applies a novel procedure that tunes the simulation to match what is measured in data. The end result of the equalization procedure and simulation tuning allows for a comparison of charge measurements in ICARUS between Monte Carlo simulation and data, showing good performance with minimal residual bias between the two. 

Context. Dual-field interferometric observations with VLTI/GRAVITY sometimes require the use of a binary calibrator. This is a binary star whose individual components remain unresolved by the interferometer, with a separation between 400 and 2000 mas for observations with the Unit Telescopes (UTs), or 1200–3000 mas for the Auxiliary Telescopes (ATs). The separation vector also needs to be predictable to within 10 mas for a proper pointing of the instrument. Aims. No list of properly vetted calibrators was available so far for dual-field observations with VLTI/GRAVITY on the UTs. Our objective is to compile such a list and make it available to the community. Methods. We identified a list of candidates from the Washington Double Star (WDS) catalogue, all with appropriate separations and brightness, scattered over the southern sky. We observed them as part of a dedicated calibration programme, determined whether these objects were true binaries (excluding higher multiplicities resolved interferometrically, but unseen by imaging), and extracted measurements of the separation vectors. We combined these new measurements with those available in the WDS to determine updated orbital parameters for all our vetted calibrators. Results. We compiled a list of 13 vetted binary calibrators for observations with VLTI/GRAVITY on the UTs, and we provide orbital estimates and astrometric predictions for each of them. We show that our list guarantees that there are always two binary calibrators at least at an airmass < 2 in the sky over the Paranal observatory at any point in time. Conclusions. Any principal investigator wishing to use the dual-field mode of VLTI/GRAVITY with the UTs can now refer to this list to select an appropriate calibrator. We encourage the use of whereistheplanet to predict the astrometry of these calibrators, which seamlessly integrates with p2Gravity for VLTI/GRAVITY dual-field observing material preparation.