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Traditional miniaturized fluorescence microscopes are critical tools for modern biology. Invariably, they struggle to simultaneously image with a high spatial resolution and a large field of view (FOV). Lensless microscopes offer a solution to this limitation. However, real-time visualization of samples is not possible with lensless imaging, as image reconstruction can take minutes to complete. This poses a challenge for usability, as real-time visualization is a crucial feature that assists users in identifying and locating the imaging target. The issue is particularly pronounced in lensless microscopes that operate at close imaging distances. Imaging at close distances requires shift-varying deconvolution to account for the variation of the point spread function (PSF) across the FOV. Here, we present a lensless microscope that achieves real-time image reconstruction by eliminating the use of an iterative reconstruction algorithm. The neural network-based reconstruction method we show here, achieves more than 10000 times increase in reconstruction speed compared to iterative reconstruction. The increased reconstruction speed allows us to visualize the results of our lensless microscope at more than 25 frames per second (fps), while achieving better than 7 µm resolution over a FOV of 10 mm². This ability to reconstruct and visualize samples in real-time empowers a more user-friendly interaction with lensless microscopes. The users are able to use these microscopes much like they currently do with conventional microscopes.

 

Foveated imaging provides a better tradeoff between situational awareness (field of view) and resolution, and is critical in long wavelength infrared regimes because of the size, weight, power, and cost of thermal sensors. We demonstrate computational foveated imaging by exploiting the ability of a meta-optical frontend to discriminate between different polarization states and a computational backend to reconstruct the captured image/video. The frontend is a three-element optic: the first element, which we call the “foveal” element, is a metalens that focuses s-polarized light at a distance off₁without affecting the p-polarized light; the second element, which we call the “perifovea” element, is another metalens that focuses p-polarized light at a distance off₂without affecting thes-polarized light. The third element is a freely rotating polarizer that dynamically changes the mixing ratios between the two polarization states. Both the foveal element (focal length=150mm; diameter=75mm) and the perifoveal element (focal length=25mm; diameter=25mm) were fabricated as polarization-sensitive, all-silicon, meta surfaces resulting in a large-aperture, 1:6 foveal expansion, thermal imaging capability. A computational backend then utilizes a deep image prior to separate the resultant multiplexed image or video into a foveated image consisting of a high resolution center and a lower-resolution large field of view context. We build a prototype system and demonstrate 12 frames per second real-time, thermal, foveated image and video capture..

 

Diffraction-limited optical imaging through scattering media has the potential to transform many applications such as airborne and space-based imaging (through the atmosphere), bioimaging (through skin and human tissue), and fiber-based imaging (through fiber bundles). Existing wavefront shaping methods can image through scattering media and other obscurants by optically correcting wavefront aberrations using high-resolution spatial light modulators—but these methods generally require (i) guidestars, (ii) controlled illumination, (iii) point scanning, and/or (iv) statics scenes and aberrations. We propose neural wavefront shaping (NeuWS), a scanning-free wavefront shaping technique that integrates maximum likelihood estimation, measurement modulation, and neural signal representations to reconstruct diffraction-limited images through strong static and dynamic scattering media without guidestars, sparse targets, controlled illumination, nor specialized image sensors. We experimentally demonstrate guidestar-free, wide field-of-view, high-resolution, diffraction-limited imaging of extended, nonsparse, and static/dynamic scenes captured through static/dynamic aberrations.

 

Lensless cameras are ultra-thin imaging systems that replace the lens with a thin passive optical mask and computation. Passive mask-based lensless cameras encode depth information in their measurements for a certain depth range. Early works have shown that this encoded depth can be used to perform 3D reconstruction of close-range scenes. However, these approaches for 3D reconstructions are typically optimization based and require strong hand-crafted priors and hundreds of iterations to reconstruct. Moreover, the reconstructions suffer from low resolution, noise, and artifacts. In this work, we proposeFlatNet3D—a feed-forward deep network that can estimate both depth and intensity from a single lensless capture. FlatNet3D is an end-to-end trainable deep network that directly reconstructs depth and intensity from a lensless measurement using an efficient physics-based 3D mapping stage and a fully convolutional network. Our algorithm is fast and produces high-quality results, which we validate using both simulated and real scenes captured using PhlatCam.

 

Lensless imaging provides opportunities to design imaging systems free from the constraints imposed by traditional camera architectures. Due to advances in imaging hardware, fabrication techniques, and new algorithms, researchers have recently developed lensless imaging systems that are extremely compact and lightweight or able to image higher-dimensional quantities. Here we review these recent advances and describe the design principles and their effects that one should consider when developing and using lensless imaging systems.

 

We present a first-of-its-kind ultra-compact intelligent camera system, dubbed i-FlatCam, including a lensless camera with a computational (Comp.) chip. It highlights (1) a predict-then-focus eye tracking pipeline for boosted efficiency without compromising the accuracy, (2) a unified compression scheme for single-chip processing and improved frame rate per second (FPS), and (3) dedicated intra-channel reuse design for depth-wise convolutional layers (DW-CONV) to increase utilization. i-FlatCam demonstrates the first eye tracking pipeline with a lensless camera and achieves 3.16 degrees of accuracy, 253 FPS, 91.49 µJ/Frame, and 6.7mm×8.9mm×1.2mm camera form factor, paving the way for next-generation Augmented Reality (AR) and Virtual Reality (VR) devices. 

Conventional continuous-wave amplitude-modulated time-of-flight (CWAM ToF) cameras suffer from a fundamental trade-off between light throughput and depth of field (DoF): a larger lens aperture allows more light collection but suffers from significantly lower DoF. However, both high light throughput, which increases signal-to-noise ratio, and a wide DoF, which enlarges the system’s applicable depth range, are valuable for CWAM ToF applications. In this work, we propose EDoF-ToF, an algorithmic method to extend the DoF of large-aperture CWAM ToF cameras by using a neural network to deblur objects outside of the lens’s narrow focal region and thus produce an all-in-focus measurement. A key component of our work is the proposed large-aperture ToF training data simulator, which models the depth-dependent blurs and partial occlusions caused by such apertures. Contrary to conventional image deblurring where the blur model is typically linear, ToF depth maps are nonlinear functions of scene intensities, resulting in a nonlinear blur model that we also derive for our simulator. Unlike extended DoF for conventional photography where depth information needs to be encoded (or made depth-invariant) using additional hardware (phase masks, focal sweeping, etc.), ToF sensor measurements naturally encode depth information, allowing a completely software solution to extended DoF. We experimentally demonstrate EDoF-ToF increasing the DoF of a conventional ToF system by 3.6 ×, effectively achieving the DoF of a smaller lens aperture that allows 22.1 × less light. Ultimately, EDoF-ToF enables CWAM ToF cameras to enjoy the benefits of both high light throughput and a wide DoF.

 

Eye tracking has become an essential human-machine interaction modality for providing immersive experience in numerous virtual and augmented reality (VR/AR) applications desiring high throughput (e.g., 240 FPS), small-form, and enhanced visual privacy. However, existing eye tracking systems are still limited by their: (1) large form-factor largely due to the adopted bulky lens-based cameras; (2) high communication cost required between the camera and backend processor; and (3) potentially concerned low visual privacy, thus prohibiting their more extensive applications. To this end, we propose, develop, and validate a lensless FlatCambased eye tracking algorithm and accelerator co-design framework dubbed EyeCoD to enable eye tracking systems with a much reduced form-factor and boosted system efficiency without sacrificing the tracking accuracy, paving the way for next-generation eye tracking solutions. On the system level, we advocate the use of lensless FlatCams instead of lens-based cameras to facilitate the small form-factor need in mobile eye tracking systems, which also leaves rooms for a dedicated sensing-processor co-design to reduce the required camera-processor communication latency. On the algorithm level, EyeCoD integrates a predict-then-focus pipeline that first predicts the region-of-interest (ROI) via segmentation and then only focuses on the ROI parts to estimate gaze directions, greatly reducing redundant computations and data movements. On the hardware level, we further develop a dedicated accelerator that (1) integrates a novel workload orchestration between the aforementioned segmentation and gaze estimation models, (2) leverages intra-channel reuse opportunities for depth-wise layers, (3) utilizes input feature-wise partition to save activation memory size, and (4) develops a sequential-write-parallel-read input buffer to alleviate the bandwidth requirement for the activation global buffer. On-silicon measurement and extensive experiments validate that our EyeCoD consistently reduces both the communication and computation costs, leading to an overall system speedup of 10.95×, 3.21×, and 12.85× over general computing platforms including CPUs and GPUs, and a prior-art eye tracking processor called CIS-GEP, respectively, while maintaining the tracking accuracy. Codes are available at https://github.com/RICE-EIC/EyeCoD. 

There has been a booming demand for integrating Convolutional Neural Networks (CNNs) powered functionalities into Internet-of-Thing (IoT) devices to enable ubiquitous intelligent "IoT cameras". However, more extensive applications of such IoT systems are still limited by two challenges. First, some applications, especially medicine-and wearable-related ones, impose stringent requirements on the camera form factor. Second, powerful CNNs often require considerable storage and energy cost, whereas IoT devices often suffer from limited resources. PhlatCam, with its form factor potentially reduced by orders of magnitude, has emerged as a promising solution to the first aforementioned challenge, while the second one remains a bottleneck. Existing compression techniques, which can potentially tackle the second challenge, are far from realizing the full potential in storage and energy reduction, because they mostly focus on the CNN algorithm itself. To this end, this work proposes SACoD, a Sensor Algorithm Co-Design framework to develop more efficient CNN-powered PhlatCam. In particular, the mask coded in the Phlat-Cam sensor and the backend CNN model are jointly optimized in terms of both model parameters and architectures via differential neural architecture search. Extensive experiments including both simulation and physical measurement on manufactured masks show that the proposed SACoD framework achieves aggressive model compression and energy savings while maintaining or even boosting the task accuracy, when benchmarking over two state-of-the-art (SOTA) designs with six datasets across four different vision tasks including classification, segmentation, image translation, and face recognition. Our codes are available at: https://github.com/RICE-EIC/SACoD. 

Abstract The simple and compact optics of lensless microscopes and the associated computational algorithms allow for large fields of view and the refocusing of the captured images. However, existing lensless techniques cannot accurately reconstruct the typical low-contrast images of optically dense biological tissue. Here we show that lensless imaging of tissue in vivo can be achieved via an optical phase mask designed to create a point spread function consisting of high-contrast contours with a broad spectrum of spatial frequencies. We built a prototype lensless microscope incorporating the ‘contour’ phase mask and used it to image calcium dynamics in the cortex of live mice (over a field of view of about 16 mm 2 ) and in freely moving Hydra vulgaris , as well as microvasculature in the oral mucosa of volunteers. The low cost, small form factor and computational refocusing capability of in vivo lensless microscopy may open it up to clinical uses, especially for imaging difficult-to-reach areas of the body.