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Abstract We present a simulation of the time-domain catalog for the Nancy Grace Roman Space Telescope’s High-Latitude Time-Domain Core Community Survey. This simulation, called the Hourglass simulation, uses the most up-to-date spectral energy distribution models and rate measurements for 10 extragalactic time-domain sources. We simulate these models through the design reference Roman Space Telescope survey: four filters per tier, a five-day cadence, over 2 yr, a wide tier of 19 deg², and a deep tier of 4.2 deg², with ∼20% of those areas also covered with prism observations. We find that a science-independent Roman time-domain catalog, assuming a signal-to-noise ratio at a max of >5, would have approximately 21,000 Type Ia supernovae, 40,000 core-collapse supernovae, around 70 superluminous supernovae, ∼35 tidal disruption events, three kilonovae, and possibly pair-instability supernovae. In total, Hourglass has over 64,000 transient objects, 11,000,000 photometric observations, and 500,000 spectra. Additionally, Hourglass is a useful data set to train machine learning classification algorithms. We show that SCONE is able to photometrically classify Type Ia supernovae with high precision (∼95%) to az> 2. Finally, we present the first realistic simulations of non-Type Ia supernovae spectral time series data from Roman’s prism. 

Abstract We report the first simultaneous observations of total electron content (TEC), radio signal scintillation, and precise point positioning (PPP) variation associated with Strong Thermal Emission Velocity Enhancement (STEVE) emissions during a 26 March 2008 storm‐time substorm. Despite that the mid‐latitude trough TEC decreases during the substorm overall, interestingly, we found an unexpected TEC enhancement (by ∼2 TECU) during STEVE. Enhancement of vertical TEC and phase scintillation was highly localized to STEVE within a thin latitudinal band of 1°. As STEVE shifted equatorward, TEC enhancement was found at and slightly poleward of the optical emission. PPP exhibited enhanced variation across a 3° latitudinal range around STEVE and indicated increased GNSS positioning error. We suggest that TEC enhancement during STEVE creates local TEC structures in the ionosphere that degrade Global Navigation Satellite Systems (GNSS) signals and PPP performance. The TEC enhancement may be created by particle precipitation, Pedersen drift across STEVE, neutral wind, or plasma instability. 

Cracking resulting from drying (constrained dehydration) poses a significant challenge in geomaterials, impacting their mechanical performance. To address this problem, extensive efforts have been made to prevent or mitigate the occurrence of cracks, with recent attention focused on the utilisation of biopolymers. This letter investigates the influence of varying concentrations of the xanthan biopolymer on the mechanical response of granular materials, examining both macro and micro scales. The strength changes of the soil were evaluated through desiccation experiments, analysing the appearance and progression of failure on the macro scale. The findings of this study demonstrate that failure (cracking) progression is mitigated and eventually eliminated by increasing the concentration of the additive xanthan. Additionally, capillary experiments were conducted to assess the changes in attraction and the development of capillary bridges on the micro-scale. They indicate that the formation of hydrogel bridges significantly enhances particle attraction, thereby increasing its macro-resistance to cracking. 

Abstract Cryogenic calorimetric experiments to search for neutrinoless double-beta decay ($$0\nu \beta \beta $$ $0\nu \beta \beta$) are highly competitive, scalable and versatile in isotope. The largest planned detector array, CUPID, is comprised of about 1500 individual Li$$_{2}$$ $_2^{}$$$^{100}$$ $_{}^{100}$MoO$$_4$$ $_4^{}$detector modules with a further scale up envisioned for a follow up experiment (CUPID-1T). In this article, we present a novel detector concept targeting this second stage with a low impedance TES based readout for the Li$$_2$$ $_2^{}$MoO$$_4$$ $_4^{}$absorber that is easily mass-produced and lends itself to a multiplexed readout. We present the detector design and results from a first prototype detector operated at the NEXUS shallow underground facility at Fermilab. The detector is a 2-cm-side cube with 21 g mass that is strongly thermally coupled to its readout chip to allow rise-times of$$\sim $$ $\sim$0.5 ms. This design is more than one order of magnitude faster than present NTD based detectors and is hence expected to effectively mitigate backgrounds generated through the pile-up of two independent two neutrino decay events coinciding close in time. Together with a baseline resolution of 1.95 keV (FWHM) these performance parameters extrapolate to a background index from pile-up as low as$$5\cdot 10^{-6}$$ $5·{10}^{-6}$ counts/keV/kg/yr in CUPID size crystals. The detector was calibrated up to the MeV region showing sufficient dynamic range for$$0\nu \beta \beta $$ $0\nu \beta \beta$searches. In combination with a SuperCDMS HVeV detector this setup also allowed us to perform a precision measurement of the scintillation time constants of Li$$_2$$ $_2^{}$MoO$$_4$$ $_4^{}$, which showed a primary component with a fast O(20 $$\upmu $$ $\mu$s) time scale. 

Abstract BackgroundHematophagous mosquitoes transmit many pathogens that cause human diseases. Pathogen acquisition and transmission occur when female mosquitoes blood feed to acquire nutrients for reproduction. The midgut epithelium of mosquitoes serves as the point of entry for transmissible viruses and parasites. ResultsWe studied midgut epithelial dynamics in five major mosquito vector species by quantifying PH3-positive cells (indicative of mitotic proliferation), the incorporation of nucleotide analogs (indicative of DNA synthesis accompanying proliferation and/or endoreplication), and the ploidy (by flow cytometry) of cell populations in the posterior midgut epithelium of adult females. Our results show that the epithelial dynamics of post-emergence maturation and of mature sugar-fed guts were similar in members of theAedes,Culex, andAnophelesgenera. In the first three days post-emergence, ~ 20% of cells in the posterior midgut region of interest incorporated nucleotide analogs, concurrent with both proliferative activity and a broad shift toward higher ploidy. In mature mosquitoes maintained on sugar, an average of 3.5% of cells in the posterior midgut region of interest incorporated nucleotide analogs from five to eight days post-emergence, with a consistent presence of mitotic cells indicating constant cell turnover. Oral bacterial infection triggered a sharp increase in mitosis and nucleotide analog incorporation, suggesting that the mosquito midgut undergoes accelerated cellular turnover in response to damage. Finally, blood feeding resulted in an increase in cell proliferation, but the nature and intensity of the response varied by mosquito species and by blood source (human, bovine, avian or artificial). InAn. gambiae, enterocytes appeared to reenter the cell cycle to increase ploidy after consuming blood from all sources except avian. ConclusionsWe saw that epithelial proliferation, differentiation, and endoreplication reshape the blood-fed gut to increase ploidy, possibly to facilitate increased metabolic activity. Our results highlight the plasticity of the midgut epithelium in mosquitoes’ physiological responses to distinct challenges. Graphical Abstract