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Chiral processes that lack mirror symmetry pervade nature from enantioselective molecular interactions to the asymmetric development of organisms. An outstanding challenge at the interface between physics and biology consists in bridging the multiple scales between microscopic and macroscopic chirality. Here, we combine theory, experiments and modern inference algorithms to study a paradigmatic example of dynamic chirality transfer across scales: the generation of tissue-scale flows from subcellular forces. The distinctive properties of our microscopic graph model and the corresponding coarse-grained viscoelasticity are that (i) net cell proliferation is spatially inhomogeneous and (ii) cellular dynamics cannot be expressed as an energy gradient. To overcome the general challenge of inferring microscopic model parameters from noisy high-dimensional data, we develop a nudged automatic differentiation algorithm (NADA) that can handle large fluctuations in cell positions observed in single tissue snapshots. This data-calibrated microscopic model quantitatively captures proliferation-driven tissue flows observed at large scales in our experiments on fibroblastoma cell cultures. Beyond chirality, our inference algorithm can be used to extract interpretable graph models from limited amounts of noisy data of living and inanimate cellular systems such as networks of convection cells and flowing foams. 

Control of particle motion is generally achieved by applying an external field that acts directly on each particle. Here, we propose a global way to manipulate the motion of a particle by dynamically changing the properties of the fluid in which it is immersed. We exemplify this principle by considering a small particle sinking in an anisotropic fluid whose viscosity depends on the shear axis. In the Stokes regime, the motion of an immersed object is fully determined by the viscosity of the fluid through the mobility matrix, which we explicitly compute for a pushpin-shaped particle. Rather than falling upright under the force of gravity, as in an isotropic fluid, the pushpin tilts to the side, sedimenting at an angle determined by the viscosity anisotropy axis. By changing this axis, we demonstrate control over the pushpin orientation as it sinks, even in the presence of noise, using a closed feedback loop. This strategy to control particle motion, that we dub viscous tweezers, could be experimentally realized in systems ranging from polyatomic fluids under external fields to chiral active fluids of spinning particles by suitably changing their direction of global alignment or anisotropy. Published by the American Physical Society2024 

Chiral fluids – such as fluids under rotation or a magnetic field as well as synthetic and biological active fluids – flow in a different way than ordinary ones. Due to symmetries broken at the microscopic level, chiral fluids may have asymmetric stress and viscosity tensors, for example giving rise to a hydrostatic torque or non-dissipative (odd) and parity-violating viscosities. In this article, we investigate the motion of rigid bodies in such an anisotropic fluid in the incompressible Stokes regime through the mobility matrix, which encodes the response of a solid body to forces and torques. We demonstrate how the form of the mobility matrix, which is usually determined by particle geometry, can be analogously controlled by the symmetries of the fluid. By computing the mobility matrix for simple shapes in a three-dimensional (3-D) anisotropic chiral fluid, we predict counterintuitive phenomena such as motion at an angle to the direction of applied forces and spinning under the force of gravity. 

Abstract Fully developed turbulence is a universal and scale-invariant chaotic state characterized by an energy cascade from large to small scales at which the cascade is eventually arrested by dissipation^1–6. Here we show how to harness these seemingly structureless turbulent cascades to generate patterns. Pattern formation entails a process of wavelength selection, which can usually be traced to the linear instability of a homogeneous state⁷. By contrast, the mechanism we propose here is fully nonlinear. It is triggered by the non-dissipative arrest of turbulent cascades: energy piles up at an intermediate scale, which is neither the system size nor the smallest scales at which energy is usually dissipated. Using a combination of theory and large-scale simulations, we show that the tunable wavelength of these cascade-induced patterns can be set by a non-dissipative transport coefficient called odd viscosity, ubiquitous in chiral fluids ranging from bioactive to quantum systems^8–12. Odd viscosity, which acts as a scale-dependent Coriolis-like force, leads to a two-dimensionalization of the flow at small scales, in contrast with rotating fluids in which a two-dimensionalization occurs at large scales⁴. Apart from odd viscosity fluids, we discuss how cascade-induced patterns can arise in natural systems, including atmospheric flows^13–19, stellar plasma such as the solar wind^20–22, or the pulverization and coagulation of objects or droplets in which mass rather than energy cascades^23–25. 

Elasticity typically refers to a material's ability to store energy, whereas viscosity refers to a material's tendency to dissipate it. In this review, we discuss fluids and solids for which this is not the case. These materials display additional linear response coefficients known as odd viscosity and odd elasticity. We first introduce odd viscosity and odd elasticity from a continuum perspective, with an emphasis on their rich phenomenology, including transverse responses, modified dislocation dynamics, and topological waves. We then provide an overview of systems that display odd viscosity and odd elasticity. These systems range from quantum fluids and astrophysical gases to active and driven matter. Finally, we comment on microscopic mechanisms by which odd viscosity and odd elasticity arise. 

The Stokes equation describes the motion of fluids when inertial forces are negligible compared with viscous forces. In this article, we explore the consequence of parity-violating and non-dissipative (i.e. odd) viscosities on Stokes flows in three dimensions. Parity-violating viscosities are coefficients of the viscosity tensor that are not invariant under mirror reflections of space, while odd viscosities are those which do not contribute to dissipation of mechanical energy. These viscosities can occur in systems ranging from synthetic and biological active fluids to magnetized and rotating fluids. We first systematically enumerate all possible parity-violating viscosities compatible with cylindrical symmetry, highlighting their connection to potential microscopic realizations. Then, using a combination of analytical and numerical methods, we analyse the effects of parity-violating viscosities on the Stokeslet solution, on the flow past a sphere or a bubble and on many-particle sedimentation. In all the cases that we analyse, parity-violating viscosities give rise to an azimuthal flow even when the driving force is parallel to the axis of cylindrical symmetry. For a few sedimenting particles, the azimuthal flow bends the trajectories compared with a traditional Stokes flow. For a cloud of particles, the azimuthal flow impedes the transformation of the spherical cloud into a torus and the subsequent breakup into smaller parts that would otherwise occur. The presence of azimuthal flows in cylindrically symmetric systems (sphere, bubble, cloud of particles) can serve as a probe for parity-violating viscosities in experimental systems.