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Datasets in which measurements of two (or more) types are obtained from a common set of samples arise in many scientific applications. A common problem in the exploratory analysis of such data is to identify groups of features of different data types that are strongly associated. A bimodule is a pair (A,B) of feature sets from two data types such that the aggregate cross-correlation between the features in A and those in B is large. A bimodule (A,B) is stable if A coincides with the set of features that have significant aggregate correlation with the features in B, and vice-versa. This paper proposes an iterative-testing based bimodule search procedure (BSP) to identify stable bimodules. Compared to existing methods for detecting cross-correlated features, BSP was the best at recovering true bimodules with sufficient signal, while limiting the false discoveries. In addition, we applied BSP to the problem of expression quantitative trait loci (eQTL) analysis using data from the GTEx consortium. BSP identified several thousand SNP-gene bimodules. While many of the individual SNP-gene pairs appearing in the discovered bimodules were identified by standard eQTL methods, the discovered bimodules revealed genomic subnetworks that appeared to be biologically meaningful and worthy of further scientific investigation. 

Double- and single-differential cross sections for inclusive charged-current ${\nu }_{\mu }$-nucleus scattering are reported for the kinematic domain 0 to $2\mathrm{GeV}/c$in three-momentum transfer and 0 to 2 GeV in available energy, at a mean ${\nu }_{\mu }$energy of 1.86 GeV. The measurements are based on an estimated 995,760 ${\nu }_{\mu }$charged-current (CC) interactions in the scintillator medium of the NOvA Near Detector. The subdomain populated by 2-particle-2-hole (2p2h) reactions is identified by the cross section excess relative to predictions for ${\nu }_{\mu }$-nucleus scattering that are constrained by a data control sample. Models for 2-particle-2-hole processes are rated by ${\chi }^2$comparisons of the predicted-versus-measured ${\nu }_{\mu }$CC inclusive cross section over the full phase space and in the restricted subdomain. Shortfalls are observed in neutrino generator predictions obtained using the theory-based València and SuSAv2 2p2h models. Published by the American Physical Society2025 

We report a search for neutrino oscillations to sterile neutrinos under a model with three active and one sterile neutrinos ( $3+1$model). This analysis uses the NOvA detectors exposed to the NuMI beam, running in neutrino mode. The data exposure, $13.6\times {10}^{20}$protons on target, doubles that previously analyzed by NOvA, and the analysis is the first to use ${\nu }_{\mu }$charged-current interactions in conjunction with neutral-current interactions. Neutrino samples in the near and far detectors are fitted simultaneously, enabling the search to be carried out over a $\mathrm{\Delta }{m}_{41}^2$range extending 2 (3) orders of magnitude above (below) $1{\mathrm{eV}}^2$. NOvA finds no evidence for active-to-sterile neutrino oscillations under the $3+1$model at 90% confidence level. New limits are reported in multiple regions of parameter space, excluding some regions currently allowed by IceCube at 90% confidence level. We additionally set the most stringent limits for anomalous ${\nu }_{\tau }$appearance for $\mathrm{\Delta }{m}_{41}^2\le 3{\mathrm{eV}}^2$. Published by the American Physical Society2025 

Abstract Measuring observables to constrain models using maximum-likelihood estimation is fundamental to many physics experiments. Wilks' theorem provides a simple way to construct confidence intervals on model parameters, but it only applies under certain conditions. These conditions, such as nested hypotheses and unbounded parameters, are often violated in neutrino oscillation measurements and other experimental scenarios. Monte Carlo methods can address these issues, albeit at increased computational cost. In the presence of nuisance parameters, however, the best way to implement a Monte Carlo method is ambiguous. This paper documents the method selected by the NOvA experiment, the profile construction. It presents the toy studies that informed the choice of method, details of its implementation, and tests performed to validate it. It also includes some practical considerations which may be of use to others choosing to use the profile construction. 

A bio-orthogonal chemistry-based approach for fluorescent labelling of ribosomal RNA is described. It involves an adenosine analogue modified with trans -cyclooctene and masked 5′-phosphate group using aryl phosphoramidate. The incorporation into rRNA has been confirmed using agarose gel electrophoresis, as well as a highly sensitive UHPLC-MS/MS method. Fluorescent labelling of rRNA has been achieved in live HeLa cells via an inverse electron demand Diels–Alder reaction with a tetrazine conjugated to an Oregon Green fluorophore. This communication describes the stepwise approach that led to the development and characterization of the probe. The results demonstrate a new strategy towards development of future fluorescent probes to investigate the biochemistry of nucleic acids. 

This Letter reports a search for charge-parity ( $CP$) symmetry violating nonstandard interactions (NSI) of neutrinos with matter using the NOvA Experiment, and examines their effects on the determination of the standard oscillation parameters. Data from ${\nu }_{\mu }\left({\overline{\nu }}_{\mu }\right)\to {\nu }_{\mu }\left({\overline{\nu }}_{\mu }\right)$and ${\nu }_{\mu }\left({\overline{\nu }}_{\mu }\right)\to {\nu }_e\left({\overline{\nu }}_e\right)$oscillation channels are used to measure the effect of the NSI parameters ${ϵ}_{e\mu }$and ${ϵ}_{e\tau }$. With 90% CL the magnitudes of the NSI couplings are constrained to be $\left|{ϵ}_{e\mu }\right|\lesssim 0.3$and $\left|{ϵ}_{e\tau }\right|\lesssim 0.4$. A degeneracy at $\left|{ϵ}_{e\tau }\right|\approx 1.8$is reported, and we observe that the presence of NSI limits sensitivity to the standard $CP$phase ${\delta }_{CP}$. Published by the American Physical Society2024 

This Letter reports the first measurement of the oscillation amplitude and frequency of reactor antineutrinos at Daya Bay via neutron capture on hydrogen using 1958 days of data. With over 3.6 million signal candidates, an optimized candidate selection, improved treatment of backgrounds and efficiencies, refined energy calibration, and an energy response model for the capture-on-hydrogen sensitive region, the relative ${\overline{\nu }}_e$rates and energy spectra variation among the near and far detectors gives ${\sin }^{2}2{\theta }_{13}=0.0759_{-0.0049}^{+0.0050}$and $\mathrm{\Delta }{m}_{32}^2=\left(2.72_{-0.15}^{+0.14}\right)\times {10}^{-3}{\mathrm{eV}}^2$assuming the normal neutrino mass ordering, and $\mathrm{\Delta }{m}_{32}^2=(-2.83_{-0.14}^{+0.15})\times {10}^{-3}{\mathrm{eV}}^2$for the inverted neutrino mass ordering. This estimate of ${\sin }^{2}2{\theta }_{13}$is consistent with and essentially independent from the one obtained using the capture-on-gadolinium sample at Daya Bay. The combination of these two results yields ${\sin }^{2}2{\theta }_{13}=0.0833\pm 0.0022$, which represents an 8% relative improvement in precision regarding the Daya Bay full 3158-day capture-on-gadolinium result. Published by the American Physical Society2024 

NOvA is a long-baseline neutrino oscillation experiment that measures oscillations in charged-current ${\nu }_{\mu }\to {\nu }_{\mu }$(disappearance) and ${\nu }_{\mu }\to {\nu }_e$(appearance) channels, and their antineutrino counterparts, using neutrinos of energies around 2 GeV over a distance of 810 km. In this work we reanalyze the dataset first examined in our previous paper [] using an alternative statistical approach based on Bayesian Markov chain Monte Carlo. We measure oscillation parameters consistent with the previous results. We also extend our inferences to include the first NOvA measurements of the reactor mixing angle ${\theta }_{13}$, where we find $0.071\le {\sin }^{2}2{\theta }_{13}\le 0.107$, and the Jarlskog invariant, where we observe no significant preference for the $CP$-conserving value $J=0$over values favoring $CP$violation. We use these results to examine the effects of constraints from short-baseline measurements of ${\theta }_{13}$using antineutrinos from nuclear reactors when making NOvA measurements of ${\theta }_{23}$. Our long-baseline measurement of ${\theta }_{13}$is shown to be consistent with the reactor measurements, supporting the general applicability and robustness of the Pontecorvo-Maki-Nakagawa-Sakata framework for neutrino oscillations. Published by the American Physical Society2024