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The deployment of vaccines across the US provides significant defense against serious illness and death from COVID-19. Over 70% of vaccine-eligible Americans are at least partially vaccinated, but there are pockets of the population that are under-vaccinated, such as in rural areas and some demographic groups (e.g. age, race, ethnicity). These unvaccinated pockets are extremely susceptible to the Delta variant, exacerbating the healthcare crisis and increasing the risk of new variants. In this paper, we describe a data-driven model that provides real-time support to Virginia public health officials by recommending mobile vaccination site placement in order to target under-vaccinated populations.more »Our strategy uses fine-grained mobility data, along with US Census and vaccination uptake data, to identify locations that are most likely to be visited by unvaccinated individuals. We further extend our model to choose locations that maximize vaccine uptake among hesitant groups. We show that the top recommended sites vary substantially across some demographics, demonstrating the value of developing customized recommendation models that integrate fine-grained, heterogeneous data sources. In addition, we used a statistically equivalent Synthetic Population to study the effect of combined demographics (eg, people of a particular race and age), which is not possible using US Census data alone. We validate our recommendations by analyzing the success rates of deployed vaccine sites, and show that sites placed closer to our recommended areas administered higher numbers of doses. Our model is the first of its kind to consider evolving mobility patterns in real-time for suggesting placement strategies customized for different targeted demographic groups. Our results will be presented at IAAI-22, but given the critical nature of the pandemic, we offer this extended version of that paper for more timely consideration of our approach and to cover additional findings.« less
Free, publicly-accessible full text available December 19, 2022
Hurt, B.; Adiga, A.; Marathe, M.; Barrett, C.(
, ArXivorg)
Tracking the COVID-19 pandemic has been a major challenge for policy makers. Although, several efforts are ongoing for accurate forecasting of cases, deaths, and hospitalization at various resolutions, few have been attempted for college campuses despite their potential to become COVID-19 hot-spots. In this paper, we present a real-time effort towards weekly forecasting of campus-level cases during the fall semester for four universities in Virginia, United States. We discuss the challenges related to data curation. A causal model is employed for forecasting with one free time-varying parameter, calibrated against case data. The model is then run forward in time tomore »obtain multiple forecasts. We retrospectively evaluate the performance and, while forecast quality suffers during the campus reopening phase, the model makes reasonable forecasts as the fall semester progresses. We provide sensitivity analysis for the several model parameters. In addition, the forecasts are provided weekly to various state and local agencies.« less
Free, publicly-accessible full text available July 6, 2022
High resolution mobility datasets have become increasingly available in the past few years and have enabled detailed models for infectious disease spread including those for COVID-19. However, there are open questions on how such a mobility data can be used effectively within epidemic models and for which tasks they are best suited. In this paper, we extract a number of graph-based proximity metrics from high resolution cellphone trace data from X-Mode and use it to study COVID-19 epidemic spread in 50 land grant university counties in the US. We present an approach to estimate the effect of mobility on casesmore »by fitting an ODE based model and performing multivariate linear regression to explain the estimated time varying transmissibility. We find that, while mobility plays a significant role, the contribution is heterogeneous across the counties, as exemplified by a subsequent correlation analysis. We subsequently evaluate the metricsโ utility for case surge prediction defined as a supervised classification problem, and show that the learnt model can predict surges with 95% accuracy and 87% F1-score.« less
The Mumbai Suburban Railways, locals, are a key transit infrastructure of the city and is crucial for resuming normal economic activity. Due to high density during transit, the potential risk of disease transmission is high, and the government has taken a wait and see approach to resume normal operations. To reduce disease transmission, policymakers can enforce reduced crowding and mandate wearing of masks. Cohorting โ forming groups of travelers that always travel together, is an additional policy to reduce disease transmission on locals without severe restrictions. Cohorting allows us to: (๐) form traveler bubbles, thereby decreasing the number of distinctmore »interactions over time; (๐๐) potentially quarantine an entire cohort if a single case is detected, making contact tracing more efficient, and (๐๐๐) target cohorts for testing and early detection of symptomatic as well as asymptomatic cases. Studying impact of cohorts using compartmental models is challenging because of the ensuing representational complexity. Agent-based models provide a natural way to represent cohorts along with the representation of the cohort members with the larger social network. This paper describes a novel multi-scale agent-based model to study the impact of cohorting strategies on COVID-19 dynamics in Mumbai. We achieve this by modeling the Mumbai urban region using a detailed agent-based model comprising of 12.4 million agents. Individual cohorts and their inter-cohort interactions as they travel on locals are modeled using local mean field approximations. The resulting multi-scale model in conjunction with a detailed disease transmission and intervention simulator is used to assess various cohorting strategies. The results provide a quantitative trade-off between cohort size and its impact on disease dynamics and well being. The results show that cohorts can provide significant benefit in terms of reduced transmission without significantly impacting ridership and or economic & social activity.« less
Carscadden, H; Kuhlman, C; Marathe, M; Ravi, SS; Rosenkrantz, D(
, International conference on complex networks and their applications)
We consider the simultaneous propagation of two contagions over a social network. We assume a threshold model for the propagation of the two contagions and use the formal framework of discrete dynamical systems. In particular, we study an optimization problem where the goal is to minimize the total number of infected nodes subject to a budget constraint on the total number of nodes that can be vaccinated. While this problem has been considered in the literature for a single contagion, our work considers the simultaneous propagation of two contagions. Since the optimization problem is NP-hard, we develop a heuristic basedmore »on a generalization of the set cover problem. Using experiments on three real-world networks, we compare the performance of the heuristic with some baseline methods.« less
Priest, J; Marathe, M; Ravi, SS; Rosenkrantz, D; Stearns, R(
, International Conference on Complex Networks and Their Applications)
We investigate questions related to the time evolution of discrete graph dynamical systems where each node has a state from {0,1}. The configuration of a system at any time instant is a Boolean vector that specifies the state of each node at that instant. We say that two configurations are similar if the Hamming distance between them is small. Also, a predecessor of a configuration B is a configuration A such that B can be reached in one step from A. We study problems related to the similarity of predecessor configurations from which two similar configurations can be reached inmore »one time step. We address these problems both analytically and experimentally. Our analytical results point out that the level of similarity between predecessors of two similar configurations depends on the local functions of the dynamical system. Our experimental results, which consider random graphs as well as small world networks, rely on the fact that the problem of finding predecessors can be reduced to the Boolean Satisfiability problem (SAT).« less
The COVID-19 pandemic represents the most significant public health disaster since the 1918 influenza pandemic. During pandemics such as COVID-19, timely and reliable spatiotemporal forecasting of epidemic dynamics is crucial. Deep learning-based time series models for forecasting have recently gained popularity and have been successfully used for epidemic forecasting. Here we focus on the design and analysis of deep learning-based models for COVID-19 forecasting. We implement multiple recurrent neural network-based deep learning models and combine them using the stacking ensemble technique. In order to incorporate the effects of multiple factors in COVID-19 spread, we consider multiple sources such as COVID-19more »confirmed and death case count data and testing data for better predictions. To overcome the sparsity of training data and to address the dynamic correlation of the disease, we propose clustering-based training for high-resolution forecasting. The methods help us to identify the similar trends of certain groups of regions due to various spatio-temporal effects. We examine the proposed method for forecasting weekly COVID-19 new confirmed cases at county-, state-, and country-level. A comprehensive comparison between different time series models in COVID-19 context is conducted and analyzed. The results show that simple deep learning models can achieve comparable or better performance when compared with more complicated models. We are currently integrating our methods as a part of our weekly forecasts that we provide state and federal authorities.« less
Reopening of colleges and universities for the Fall semester of 2020 across the United States has caused signi ficant COVID-19 case spikes, requiring reactive responses such as temporary closures and switching to online learning. Until sufficient levels of immunity are reached through vaccination, Institutions of Higher Education will need to balance academic operations with COVID-19 spread risk within and outside the student community. In this work, we study the impact of proximity statistics obtained from high resolution mobility traces in predicting case rate surges in university counties. We focus on 50 land-grant university counties (LGUCs) across the country and showmore »high correlation (PCC > 0.6) between proximity statistics and COVID-19 case rates for several LGUCs during the period around Fall 2020 reopenings. These observations provide a lead time of up to 3 weeks in preparing resources and planning containment efforts. We also show how features such as total population, population affiliated with university, median income and case rate intensity could explain some of the observed high correlation. We believe these easily explainable mobility metrics along with other disease surveillance indicators can help universities be better prepared for the Spring 2021 semester.« less
As the complexity of our food systems increases, they also become susceptible to unanticipated natural and human-initiated events. Commodity trade networks are a critical component of our food systems in ensuring food availability. We develop a generic data-driven framework to construct realistic agricultural commodity trade networks. Our work is motivated by the need to study food flows in the context of biological invasions. These networks are derived by fusing gridded, administrative-level, and survey datasets on production, trade, and consumption. Further, they are periodic temporal networks reflecting seasonal variations in production and trade of the crop. We apply this approach tomore »create networks of tomato flow for two regions โ Senegal and Nepal. Using statistical methods and network analysis, we gain insights into spatiotemporal dynamics of production and trade. Our results suggest that agricultural systems are increasingly vulnerable to attacks through trade of commodities due to their vicinity to regions of high demand and seasonal variations in production and flows.« less
This research measures the epidemiological and economic impact of COVID-19 spread in the US under different mitigation scenarios, comprising of non-pharmaceutical interventions. A detailed disease model of COVID-19 is combined with a model of the US economy to estimate the direct impact of labor supply shock to each sector arising from morbidity, mortality, and lockdown, as well as the indirect impact caused by the interdependencies between sectors. During a lockdown, estimates of jobs that are workable from home in each sector are used to modify the shock to labor supply. Results show trade-o s between economic losses, and lives savedmore »and infections averted are non-linear in compliance to social distancing and the duration of lockdown. Sectors that are worst hit are not the labor-intensive sectors such as Agriculture and Construction, but the ones with high valued jobs such as Professional Services, even after the teleworkability of jobs is accounted for. Additionally, the findings show that a low compliance to interventions can be overcome by a longer shutdown period and vice versa to arrive at similar epidemiological impact but their net effect on economic loss depends on the interplay between the marginal gains from averting infections and deaths, versus the marginal loss from having healthy workers stay at home during the shutdown.« less
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