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Abstract The Lyme disease spirocheteBorrelia burgdorfericauses an infection with diverse clinical outcomes, which can include arthritis as well as cardiac and neurological manifestations.B. burgdorferiexpresses different outer surface lipoproteins at different stages in its infectious cycle, many of which are adhesins. Utilizing atomic force microscopy (AFM), we obtained topography images and force–distance curves of wild-typeB. burgdorferiand mutant strains encoding different complements of surface lipoproteins. AFM data show that a reduced number of genome-encoded lipoproteins correlates with decreased binding probability, weakens unbinding force, and negatively affects cell elasticity. 

Fabrication and acoustic performance of a microelectromechanical systems (MEMS) microphone are presented. The microphone utilizes an unusual electrostatic sensing scheme that causes the sensing electrode to move away, or levitate from the biasing electrode as the bias voltage is applied. This approach differs from existing electrostatic sensors and completely avoids the usual collapse, or pull-in instability. In this study, our goal is to fabricate a MEMS microphone whose sensitivity could be improved simply by increasing the bias voltage, without suffering from pull-in instability. The microphone is tested in our anechoic chamber and a read-out circuit is used to obtain electrical signals in response to sound pressure at various bias voltages. Experimental results show that the sensitivity increases approximately linearly with bias voltage for bias voltages from 40 volts to 100 volts. The ability to design electrostatic sensors without concerns about pull-in failure can enable a wide-range of promising sensor designs. 

We present a MEMS microphone that converts the mechanical motion of a diaphragm, generated by acoustic waves, to an electrical output voltage by capacitive fingers. The sensitivity of a microphone is one of the most important properties of its design. The sensitivity is proportional to the applied bias voltage. However, it is limited by the pull-in voltage, which causes the parallel plates to collapse and prevents the device from functioning properly. The presented MEMS microphone is biased by repulsive force instead of attractive force to avoid pull-in instability. A unit module of the repulsive force sensor consists of a grounded moving finger directly above a grounded fixed finger placed between two horizontally seperated voltage fixed fingers. The moving finger experiences an asymmetric electrostatic field that generates repulsive force that pushes it away from the substrate. Because of the repulsive nature of the force, the applied voltage can be increased for better sensitivity without the risk of pull-in failure. To date, the repulsive force has been used to engage a MEMS actuator such as a micro-mirror, but we now apply it for a capacitive sensor. Using the repulsive force can revolutionize capacitive sensors in many applications because they will achieve better sensitivity. Our simulations show that the repulsive force allows us to improve the sensitivity by increasing the bias voltage. The applied voltage and the back volume of a standard microphone have stiffening effects that significantly reduce its sensitivity. We find that proper design of the back volume and capacitive fingers yield promising results without pull-in instability.