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PurposeMachine learning to enable precise, non-invasive detection of cerebral amyloid-beta (Aβ) pathology by integrating cognitive assessments, plasma biomarkers, and structural neuroimaging. MethodsWe developed an explainable multimodal machine-learning framework to predict amyloid PET visual read status using plasma biomarkers, cognitive assessments, APOE genotype, demographic variables, and structural MRI measurements. The development cohort consisted of 170 participants from the 1Florida Alzheimer’s Disease Research Center (ADRC) and 129 participants from the ADNI4 cohort. Machine-learning pipelines were evaluated using combinations of five classifiers and multiple feature-selection approaches with Bayesian hyperparameter optimization and stratified five-fold cross-validation. Model interpretability was assessed using SHapley Additive exPlanations (SHAP). ResultsEnsemble methods consistently outperformed linear and distance-based classifiers. The optimal pipeline, XGBoost with mutual-information feature selection, achieved a mean AUC of 0.891 ± 0.048 and a recall of 0.84. SHAP analyses identified the plasma p-tau217/Aβ42 ratio as the most influential predictor, followed by plasma p-tau217, p-tau181, MMSE, and APOE ε4 status. Structural MRI variables provided complementary predictive information. ADNI4 evaluation yielded a mean AUC of 0.545, while training on ADRC and testing on ADNI4 achieved an AUC of 0.636 and an overall accuracy of 63%. Importantly, plasma p-tau217/Aβ42 and p-tau217 remained the dominant predictors across cohorts. ConclusionMultimodal machine learning can predict amyloid PET status while providing biologically interpretable explanations. Plasma tau and amyloid-related biomarkers carried the strongest predictive signal, while cognition, APOE genotype, and MRI refined classification decisions. External validation highlighted the challenges of cohort heterogeneity and domain shift but demonstrated preservation of biologically meaningful biomarker relationships. 

One of the persistent challenges in multispectral image analysis is the interference caused by dense cloud cover and its resulting shadows, which can significantly obscure surface features. This becomes especially problematic when attempting to monitor surface changes over time using satellite imagery, such as from Landsat-8. In this study, rather than simply masking visual obstructions, we aimed to investigate the role and influence of clouds within the spectral data itself. To achieve this, we employed Independent Component Analysis (ICA), a statistical method capable of decomposing mixed signals into independent source components. By applying ICA to selected Landsat-8 bands and analyzing each component individually, we assessed the extent to which cloud signatures are entangled with surface data. This process revealed that clouds contribute to multiple ICA components simultaneously, indicating their broad spectral influence. With this influence on multiple wavebands, we managed to configure a set of components that could perfectly delineate the extent and location of clouds. Moreover, because Landsat-8 lacks cloud-penetrating wavebands, such as those in the microwave range (e.g., SAR), the surface information beneath dense cloud cover is not captured at all, making it physically impossible for ICA to recover what is not sensed in the first place. Despite these limitations, ICA proved effective in isolating and delineating cloud structures, allowing us to selectively suppress them in reconstructed images. Additionally, the technique successfully highlighted features such as water bodies, vegetation, and color-based land cover differences. These findings suggest that while ICA is a powerful tool for signal separation and cloud-related artifact suppression, its performance is ultimately constrained by the spectral and spatial properties of the input data. Future improvements could be realized by integrating data from complementary sensors—especially those operating in cloud-penetrating wavelengths—or by using higher spectral resolution imagery with narrower bands. 

Road extraction is a sub-domain of remote sensing applications; it is a subject of extensive and ongoing research. The procedure of automatically extracting roads from satellite imagery encounters significant challenges due to the multi-scale and diverse structures of roads; improvement in this field is needed. Convolutional neural networks (CNNs), especially the DeepLab series known for its proficiency in semantic segmentation due to its efficiency in interpreting multi-scale objects’ features, address some of these challenges caused by the varying nature of roads. The present work proposes the utilization of DeepLabV3+, the latest version of the DeepLab series, by introducing an innovative Dense Depthwise Dilated Separable Spatial Pyramid Pooling (DenseDDSSPP) module and integrating it in the place of the conventional Atrous Spatial Pyramid Pooling (ASPP) module. This modification enhances the extraction of complex road structures from satellite images. This study hypothesizes that the integration of DenseDDSSPP with a CNN backbone network and a Squeeze-and-Excitation block will generate an efficient dense feature map by focusing on relevant features, leading to more precise and accurate road extraction from remote sensing images. The Results Section presents a comparison of our model’s performance against state-of-the-art models, demonstrating better results that highlight the effectiveness and success of the proposed approach. 

Image-to-Image translation in Generative Artificial Intelligence (Generative AI) has been a central focus of re- search, with applications spanning healthcare, remote sensing, physics, chemistry, photography, and more. Among the numerous methodologies, Generative Adversarial Networks (GANs) with contrastive learning have been particularly successful. This study aims to demonstrate that the Kolmogorov-Arnold Network (KAN) can effectively replace the Multi-layer Perceptron (MLP) method in generative AI, particularly in the subdomain of image-to-image translation, to achieve better generative quality. Our novel approach replaces the two-layer MLP with a two- layer KAN in the existing Contrastive Unpaired Image-to-Image Translation (CUT) model, developing the KAN-CUT model. This substitution favors the generation of more informative features in low-dimensional vector representations, which contrastive learn- ing can utilize more effectively to produce high-quality images in the target domain. Extensive experiments, detailed in the results section, demonstrate the applicability of KAN in conjunction with contrastive learning and GANs in Generative AI, particularly for image-to-image translation. This work suggests that KAN could be a valuable component in the broader generative AI domain. 

Image-to-Image translation in Generative Artificial Intelligence (Generative AI) has been a central focus of research, with applications spanning healthcare, remote sensing, physics, chemistry, photography, and more. Among the numerous methodologies, Generative Adversarial Networks (GANs) with contrastive learning have been particularly successful. This study aims to demonstrate that the Kolmogorov-Arnold Network (KAN) can effectively replace the Multi-layer Perceptron (MLP) method in generative AI, particularly in the subdomain of image-to-image translation, to achieve better generative quality. Our novel approach replaces the two-layer MLP with a two-layer KAN in the existing Contrastive Unpaired Image-to-Image Translation (CUT) model, developing the KAN-CUT model. This substitution favors the generation of more informative features in low-dimensional vector representations, which contrastive learning can utilize more effectively to produce high-quality images in the target domain. Extensive experiments, detailed in the results section, demonstrate the applicability of KAN in conjunction with contrastive learning and GANs in Generative AI, particularly for image-to-image translation. This work suggests that KAN could be a valuable component in the broader generative AI domain. 

Image-to-Image translation in Generative Artificial Intelligence (Generative AI) has been a central focus of re- search, with applications spanning healthcare, remote sensing, physics, chemistry, photography, and more. Among the numerous methodologies, Generative Adversarial Networks (GANs) with contrastive learning have been particularly successful. This study aims to demonstrate that the Kolmogorov-Arnold Network (KAN) can effectively replace the Multi-layer Perceptron (MLP) method in generative AI, particularly in the subdomain of image-to-image translation, to achieve better generative quality. Our novel approach replaces the two-layer MLP with a two- layer KAN in the existing Contrastive Unpaired Image-to-Image Translation (CUT) model, developing the KAN-CUT model. This substitution favors the generation of more informative features in low-dimensional vector representations, which contrastive learn- ing can utilize more effectively to produce high-quality images in the target domain. Extensive experiments, detailed in the results section, demonstrate the applicability of KAN in conjunction with contrastive learning and GANs in Generative AI, particularly for image-to-image translation. This work suggests that KAN could be a valuable component in the broader generative AI domain.