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Using methane as a reagent to synthesize high-value chemicals and high-energy density fuels through C−C coupling has attracted intense attention in recent decades, as it avoids completely breaking all C−H bonds in CH4. In the present study, we demonstrated that the coupling of HCHO with the CH3 species from CH4 activation to produce ethanol can be accomplished on the single Pd atom−In2O3 catalyst based on the results of density functional theory (DFT) calculations. The results show that the supported single Pd atom stabilizes the CH3 species following the activation of one C−H bond of CH4, while HCHO adsorbs on the neighboring In site. Facile C−C coupling of HCHO with the methyl species is achieved with an activation barrier of 0.56 eV. We further examined the C−C coupling on other single metal atoms, including Ni, Rh, Pt, and Ag, supported on In2O3 by following a similar pathway and found that a balance of the three key steps for ethanol formation, i.e., CH4 activation, C−C coupling, and ethoxy hydrogenation, was achieved on Pd/In2O3. Taking the production of acetaldehyde and ethylene on the Pd/In2O3 catalyst into consideration, the DFT-based microkinetic analysis indicates that ethanol is the dominant product on the Pd/In2O3 catalyst. The facile C−C coupling between HCHO and dissociated CH4 makes formaldehyde a potential C1 source in the conversion and utilization of methane through an energy- and atom-efficient process. 

This study investigates the potential use of circulating extracellular vesicles’ (EVs) DNA and protein content as biomarkers for traumatic brain injury (TBI) in a mouse model. Despite an overall decrease in EVs count during the acute phase, there was an increased presence of exosomes (CD63+ EVs) during acute and an increase in microvesicles derived from microglia/macrophages (CD11b+ EVs) and astrocytes (ACSA-2+ EVs) in post-acute TBI phases, respectively. Notably, mtDNA exhibited an immediate elevation post-injury. Neuronal (NFL) and microglial (Iba1) markers increased in the acute, while the astrocyte marker (GFAP) increased in post-acute TBI phases. Novel protein biomarkers (SAA, Hp, VWF, CFD, CBG) specific to different TBI phases were also identified. Biostatistical modeling and machine learning identified mtDNA and SAA as decisive markers for TBI detection. These findings emphasize the importance of profiling EVs’ content and their dynamic release as an innovative diagnostic approach for TBI in liquid biopsies 

Abstract This study used radar observations and a high-resolution numerical simulation to explore the interactions between an mesoscale convective system (MCS), cold pool outflows, and atmospheric bores in a non-uniform baroclinic environment. The bores were generated by a nocturnal MCS that occurred on 2–3 June 2017 over the southern North China Plain. The goal of this investigation is to determine how the structure of bores varied within this non-uniform environment and whether and how the bores would maintain the MCS and alter its structure. To the southwest of the MCS, where there was large CAPE and a well-mixed boundary layer, discrete convection initiation occurred behind a single radar fine line (RFL) maintaining the propagation of the MCS. To the southeast of the MCS, multiple RFLs were found suggesting the generation of an undular bore in an environment containing an intense nocturnal stable boundary layer with dry upper layers and little CAPE. Hydraulic and nonlinear theory were applied to the simulation of the MCS revealing that the differences in the bore evolution depended on both the characteristics of the cold pool and the variations in the ambient environment. Thus, the characteristics of the ambient environment and the associated differences in bore structure impacted the maintenance and organization of the MCS. This study implies the importance of an accurate representation of the low-level ambient environment and the microphysics and kinematics within the MCS to accurately simulate and forecast cold pools, the generation and evolution of bores, and their impact on nocturnal MCSs.