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Large-scale production and waste of plastic materials have resulted in widespread environmental contamination by the breakdown product of bulk plastic materials to micro- and nanoplastics (MNPs). The small size of these particles enables their suspension in the air, making pulmonary exposure inevitable. Previous work has demonstrated that xenobiotic pulmonary exposure to nanoparticles during gestation leads to maternal vascular impairments, as well as cardiovascular dysfunction within the fetus. Few studies have assessed the toxicological consequences of maternal nanoplastic (NP) exposure; therefore, the objective of this study was to assess maternal and fetal health after a single maternal pulmonary exposure to polystyrene NP in late gestation. We hypothesized that this acute exposure would impair maternal and fetal cardiovascular function. Pregnant rats were exposed to nanopolystyrene on gestational day 19 via intratracheal instillation. 24 h later, maternal and fetal health outcomes were evaluated. Cardiovascular function was assessed in dams using vascular myography ex vivo and in fetuses in vivo function was measured via ultrasound. Both fetal and placental weight were reduced after maternal exposure to nanopolystyrene. Increased heart weight and vascular dysfunction in the aorta were evident in exposed dams. Maternal exposure led to vascular dysfunction in the radial artery of the uterus, a resistance vessel that controls blood flow to the fetoplacental compartment. Function of the fetal heart, fetal aorta, and umbilical artery after gestational exposure was dysregulated. Taken together, these data suggest that exposure to NPs negatively impacts maternal and fetal health, highlighting the concern of MNPs exposure on pregnancy and fetal development.

 

ABSTRACT We present new Large Binocular Telescope, Hubble Space Telescope, and Spitzer Space Telescope data for the failed supernova candidate N6946-BH1. We also report an unsuccessful attempt to detect the candidate with Chandra. The ∼300 000 $\, \mathrm{L}_\odot$ red supergiant progenitor underwent an outburst in 2009 and has since disappeared in the optical. In the LBT data from 2008 May through 2019 October, the upper limit on any increase in the R-band luminosity of the source is $2000 \, \mathrm{L}_\odot$. HST and Spitzer observations show that the source continued to fade in the near-IR and mid-IR, fading by approximately a factor of 2 between 2015 October and 2017 September to 2900 $\, \mathrm{L}_\odot$ at Hband (F160W). Models of the spectral energy distribution are inconsistent with a surviving star obscured either by an ongoing wind or dust formed in the transient. The disappearance of N6946-BH1 remains consistent with a failed supernova, but the post-failure phenomenology requires further theoretical study. 

ABSTRACT We present updated results of the Large Binocular Telescope Search for Failed Supernovae. This search monitors luminous stars in 27 nearby galaxies with a current baseline of 11 yr of data. We re-discover the failed supernova (SN) candidate N6946-BH1 as well as a new candidate, M101-OC1. M101-OC1 is a blue supergiant that rapidly disappears in optical wavelengths with no evidence for significant obscuration by warm dust. While we consider other options, a good explanation for the fading of M101-OC1 is a failed SN, but follow-up observations are needed to confirm this. Assuming only one clearly detected failed SN, we find a failed SN fraction $f = 0.16^{+0.23}_{-0.12}$ at 90 per cent confidence. We also report on a collection of stars that show slow (∼decade), large amplitude (ΔL/L > 3) luminosity changes. 

Studies on graduate education have shown that underrepresented minorities finish PhDs in engineering at lesser rates and longer timeframes than their majority counterparts. While multiple interventions have been designed for students considering their decision to apply for graduate school or students completing their doctoral journey, few focus on the transition into those doctoral programs. To prepare minoritized doctoral students for this transition to the Ph. D., we developed and researched the Rising Doctoral Institute (RDI). The RDI is a four-day summer workshop for incoming doctoral students who identify as underrepresented in engineering and intend to begin graduate school in the Fall semester. This paper aims to discuss the process through which we developed the RDI and our initial research findings. We conclude with our plan to disseminate these workshops across multiple US institutions using a change-theory informed dissemination model. 

ABSTRACT SN 1954J in NGC 2403 and SN 1961V in NGC 1058 were two luminous transients whose definitive classification as either non-terminal eruptions or supernovae remains elusive. A critical question is whether a surviving star can be significantly obscured by dust formed from material ejected during the transient. We use three lines of argument to show that the candidate surviving stars are not significantly optically extinct (τ ≲ 1) by dust formed in the transients. First, we use SED fits to new HST optical and near-IR photometry. Secondly, neither source is becoming brighter as required by absorption from an expanding shell of ejected material. Thirdly, the ejecta masses implied by the Hα luminosities are too low to produce significant dust absorption. The latter two arguments hold independent of the dust properties. The Hα fluxes should also be declining with time as t−3, and this seems not to be observed. As a result, it seems unlikely that recently formed dust can be responsible for the present faintness of the sources compared to their progenitors, although this can be verified with the James Webb Space Telescope. This leaves three possibilities: (1) the survivors were misidentified; (2) they are intrinsically less luminous; (3) SN 1954J and SN 1961V were true supernovae. 

ABSTRACT M31-LRN-2015 is a likely stellar merger discovered in the Andromeda Galaxy in 2015. We present new optical to mid-infrared photometry and optical spectroscopy for this event. Archival data show that the source started to brighten ∼2 yr before the nova event. During this precursor phase, the source brightened by ∼3 mag. The light curve at 6 and 1.5 months before the main outburst may show periodicity, with periods of 16 ± 0.3 and 28.1 ± 1.4 d, respectively. This complex emission may be explained by runaway mass-loss from the system after the binary undergoes Roche lobe overflow, leading the system to coalesce in tens of orbital periods. While the progenitor spectral energy distribution shows no evidence of pre-existing warm dust in the system, the remnant forms an optically thick dust shell at approximately four months after the outburst peak. The optical depth of the shell increases dramatically after 1.5 yr, suggesting the existence of shocks that enhance the dust formation process. We propose that the merger remnant is likely an inflated giant obscured by a cooling shell of gas with mass ∼0.2 M⊙ ejected at the onset of the common envelope phase.