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  1. Abstract INTRODUCTION

    Older adults represent the fastest growing segment of the homeless community. Little is known about the prevalence of dementia and mild cognitive impairment (MCI) in this population.

    METHODS

    Dementia and MCI screening using the Montreal Cognitive Assessment (MoCA) was incorporated into the standard senior evaluation for adult clients aged ≥ 55 in a large emergency homeless shelter.

    RESULTS

    In a 6‐week period, 104 of 112 (92.9%) assessments were positive for dementia or MCI using a standard cutoff of 26, and 81 (72.3%) were positive using a conservative cutoff of 23. There was no significant difference in MoCA scores based on sex or education level, and no significant correlation between age and MoCA score.

    DISCUSSION

    Older adults experiencing homelessness may have a high likelihood of dementia or MCI. Routine MoCA screening in older adults experiencing homelessness is feasible and can help to identify services needed to successfully exit homelessness.

     
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    Free, publicly-accessible full text available May 1, 2025
  2. Objective

    This study examines low-, medium-, and high-performing Human-Autonomy Teams’ (HATs’) communication strategies during various technological failures that impact routine communication strategies to adapt to the task environment.

    Background

    Teams must adapt their communication strategies during dynamic tasks, where more successful teams make more substantial adaptations. Adaptations in communication strategies may explain how successful HATs overcome technological failures. Further, technological failures of variable severity may alter communication strategies of HATs at different performance levels in their attempts to overcome each failure.

    Method

    HATs in a Remotely Piloted Aircraft System-Synthetic Task Environment (RPAS-STE), involving three team members, were tasked with photographing targets. Each triad had two randomly assigned participants in navigator and photographer roles, teaming with an experimenter who simulated an AI pilot in a Wizard of Oz paradigm. Teams encountered two different technological failures, automation and autonomy, where autonomy failures were more challenging to overcome.

    Results

    High-performing HATs calibrated their communication strategy to the complexity of the different failures better than medium- and low-performing teams. Further, HATs adjusted their communication strategies over time. Finally, only the most severe failures required teams to increase the efficiency of their communication.

    Conclusion

    HAT effectiveness under degraded conditions depends on the type of communication strategies enacted by the team. Previous findings from studies of all-human teams apply here; however, novel results suggest information requests are particularly important to HAT success during failures.

    Application

    Understanding the communication strategies of HATs under degraded conditions can inform training protocols to help HATs overcome failures.

     
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  3. Introduction

    While vaccines are crucial for disease prevention, disparities in vaccination coverage persist among youths aged 10 to 29 years, including within the United States. Serious games are emerging as a new strategy to address vaccine hesitancy. This systematic review aimed to aggregate and assess the current evidence on game-based interventions to improve youth vaccination rates, evaluating their impact and identifying factors influencing their effectiveness.

    Methods

    This systematic review was conducted through a meticulous search and evaluation of literature from databases including PubMed, Cumulative Index to Nursing and Allied Health Literature database, ProQuest platform, Cochrane Library, and Google Scholar. Studies were included if they (a) were designed with the purpose of improving youth vaccination rates; (b) were published in English; (c) were published between January 2011 and June 2023; and (d) evaluated the effect of game-based interventions. Search terms included Medical Subject Headings terms and keywords of the eligible articles.

    Results

    Out of 269 studies, 11 were included in the final analysis of this review. The earliest study dated back to 2013, with 5 being randomized controlled trial and 6 studies incorporating theoretical models in their design or outcome measures. The findings indicated a generally positive effect of game-based interventions on vaccine-related knowledge. However, the impact on actual vaccine uptake was limited. In-game avatar customization and collaboration games were found as effective tools for player engagement.

    Conclusion

    The review findings indicated that serious games boost vaccine knowledge but lack strong evidence for influencing youth vaccine uptake. More rigorous research and tailored game designs are needed to determine the effectiveness of game-based interventions and effectively address the diverse needs of youth in vaccine decision-making.

     
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  4. Abstract Background

    Forward-looking, democratically oriented governance is needed to ensure that human genome editing serves rather than undercuts public values. Scientific, policy, and ethics communities have recognized this necessity but have demonstrated limited understanding of how to fulfill it. The field of bioethics has long attempted to grapple with the unintended consequences of emerging technologies, but too often such foresight has lacked adequate scientific grounding, overemphasized regulation to the exclusion of examining underlying values, and failed to adequately engage the public.

    Methods

    This research investigates the application of scenario planning, a tool developed in the high-stakes, uncertainty-ridden world of corporate strategy, for the equally high-stakes and uncertain world of the governance of emerging technologies. The scenario planning methodology is non-predictive, looking instead at a spread of plausible futures which diverge in their implications for different communities’ needs, cares, and desires.

    Results

    In this article we share how the scenario development process can further understandings of the complex and dynamic systems which generate and shape new biomedical technologies and provide opportunities to re-examine and re-think questions of governance, ethics and values. We detail the results of a year-long scenario planning study that engaged experts from the biological sciences, bioethics, social sciences, law, policy, private industry, and civic organizations to articulate alternative futures of human genome editing.

    Conclusions

    Through sharing and critiquing our methodological approach and results of this study, we advance understandings of anticipatory methods deployed in bioethics, demonstrating how this approach provides unique insights and helps to derive better research questions and policy strategies.

     
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  5. Background

    The prevalence of human papillomavirus (HPV) and its related cancers is a major global concern. In the United States, routine HPV vaccination is recommended for youth aged 11 or 12 years. Despite HPV being the most common sexually transmitted infection and the vaccine’s proven efficacy, the vaccination rate among US youth remains below the recommended 80% completion rate. Mobile health (mHealth) interventions have demonstrated promise in improving health. Examining and synthesizing the current evidence about the impact of mHealth interventions on vaccination coverage in youth and intervention characteristics could guide future mHealth interventions aimed at mitigating the vaccination gap and disease burden.

    Objective

    This study aims to conduct a systematic review to assess the effectiveness of mHealth interventions on parental intent to vaccinate youth against HPV and youth’s vaccine uptake.

    Methods

    We searched empirical papers through databases including Google Scholar, PubMed, CINAHL, PsycINFO, and Cochrane Library. The inclusion criteria were the following: (1) published between January 2011 and December 2022; (2) using mHealth aimed to improve HPV vaccination rate; (3) targeted unvaccinated youth or their parents; and (4) measured HPV-related knowledge, vaccination intention, or vaccine uptake. Overall, 3 researchers screened and appraised the quality of the eligible papers using the Melnyk Levels of Evidence and the Cochrane Grading of Recommendations Assessment, Development, and Evaluation methodology. Disagreements in search results and result interpretation were resolved through consensus.

    Results

    Overall, 17 studies that met the inclusion criteria were included in the final review. Most studies were conducted in the United States (14/17, 82%), used a randomized controlled trial design (12/17, 71%), and adopted behavior change theories or a culture-centric approach (10/17, 59%). mHealth interventions included SMS text message reminders, motivational SMS text messages, computer-tailored or tablet-tailored interventions, smartphone apps, web-based tailored interventions, social media (Facebook) campaigns, digital videos, and digital storytelling interventions. Approximately 88% (15/17) of the mHealth interventions demonstrated positive effects on knowledge, intention, or behaviors related to HPV vaccination. Overall, 12% (2/17) reported limited or no intervention impact on vaccine uptake or vaccine series completion. Effective vaccine uptake was commonly seen in interventions based on behavior change theories and those that provided culturally relevant information.

    Conclusions

    This systematic review identified the impact of mHealth interventions among unvaccinated youth and their parents, which showed improvement in HPV-related knowledge, vaccination intention, or vaccine initiation. The interventions that incorporated theories and culture-centric approaches revealed the most promising results. Although these outcomes are encouraging, future studies are needed to investigate factors associated with the success of interventions using SMS text messaging or social media. More studies are also needed for a better understanding of the intervention elements that boost the responses of age-specific and ethnicity-specific populations.

     
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  6. Abstract

    In response to calls for public engagement on human genome editing (HGE), which intensified after the 2018 He Jiankui scandal that resulted in the implantation of genetically modified embryos, we detail an anticipatory approach to the governance of HGE. By soliciting multidisciplinary experts’ input on the drivers and uncertainties of HGE development, we developed a set of plausible future scenarios to ascertain publics values—specifically, their hopes and concerns regarding the novel technology and its applications. In turn, we gathered a subset of multidisciplinary experts to propose governance recommendations for HGE that incorporate identified publics’ values. These recommendations include: (1) continued participatory public engagement; (2) international harmonization and transparency of multiple governance levers such as professional and scientific societies, funders, and regulators; and (3) development of a formal whistleblower framework.

     
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    Free, publicly-accessible full text available March 25, 2025
  7. Abstract

    This work details the partially observable markov decision process (POMDP) and the point-based value iteration (PBVI) algorithms for use in multisensor systems, specifically, a sensor system capable of heart rate (HR) estimation through wearable photoplethysmography (PPG) and accelerometer signals. PPG sensors are highly susceptible to motion artifact (MA); however, current methods focus more on overall MA filters, rather than action specific filtering. An end-to-end embedded human activity recognition (HAR) System is developed to represent the observation uncertainty, and two action specific PPG MA reducing filters are proposed as actions. PBVI allows optimal action decision-making based on an uncertain observation, effectively balancing correct action choice and sensor system cost. Two central systems are proposed to accompany these algorithms, one for unlimited observation access and one for limited observation access. Through simulation, it can be shown that the limited observation system performs optimally when sensor cost is negligible, while limited observation access performs optimally when a negative reward for sensor use is considered. The final general framework for POMDP and PBVI was applied to a specific HR estimation example. This work can be expanded on and used as a basis for future work on similar multisensor system.

     
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  8. Abstract

    Collecting gait data and providing haptic feedback are essential for the safety and efficiency of robot-based rehabilitation. However, readily available devices that can perform both are scarce. This work presents a novel method for mutual sensing and haptic feedback, through the development of an inflatable soft haptic sensor (ISHASE). The design, modeling, and characterization of ISHASE are discussed. Four ISHASEs are embedded in the insole of a shoe to measure ground reaction forces and provide haptic feedback. Four participants were recruited to evaluate the performance of ISHASE as a sensor and haptic device. Experimental results indicate that ISHASE can accurately estimate user’s ground reaction forces while walking, with a maximum and a minimum accuracy of 91% and 85%, respectively. Haptic feedback was delivered to four different locations under the foot, and users could identify the location with an average 92% accuracy. A case study that exemplifies a rehabilitation scenario is presented to demonstrate ISHASE’s usefulness for mutual sensing and haptic feedback.

     
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  9. Abstract

    Cities across the globe are striving to produce viable solutions to pressing urban sustainability and resilience problems. Despite aspirations, municipal governments often need additional support in terms of knowledge, capacity, or resources to achieve transformations. Partnerships between cities and universities are one mechanism for co-producing knowledge and achieving sustained progress on complex challenges. When properly structured and effectively managed, city-university partnerships (CUPs) are purported to increase transformative capacity in city administrations and support actions which accelerate urban transformations; but these outcomes are not always achieved. As CUPs grow in numbers, there is a pressing need to identify which principles and practices facilitate transformation. Therefore, we used iterative reflective focus group sessions to develop in-depth case studies of five sustainability and resilience CUPs across three countries. The CUPs were cross-compared to explore the partnership dynamics and management practices that aid progress towards transformative goals. Observations were then related to transformative capacity typologies, and mapped to the newly described project-partnership cycle – which is useful for the management of transformative partnerships.

     
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  10. Abstract

    Artificial General Intelligence (AGI) is the next and forthcoming evolution of Artificial Intelligence (AI). Though there could be significant benefits to society, there are also concerns that AGI could pose an existential threat. The critical role of Human Factors and Ergonomics (HFE) in the design of safe, ethical, and usable AGI has been emphasized; however, there is little evidence to suggest that HFE is currently influencing development programs. Further, given the broad spectrum of HFE application areas, it is not clear what activities are required to fulfill this role. This article presents the perspectives of 10 researchers working in AI safety on the potential risks associated with AGI, the HFE concepts that require consideration during AGI design, and the activities required for HFE to fulfill its critical role in what could be humanity's final invention. Though a diverse set of perspectives is presented, there is broad agreement that AGI potentially poses an existential threat, and that many HFE concepts should be considered during AGI design and operation. A range of critical activities are proposed, including collaboration with AGI developers, dissemination of HFE work in other relevant disciplines, the embedment of HFE throughout the AGI lifecycle, and the application of systems HFE methods to help identify and manage risks.

     
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