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1. Fairness via AI: Bias Reduction in Medical Information

   Dori-Hacohen, S. ; Montenegro, R. ; Murai, F. ; Hale, S. A. ; Sung, K. ; Blain, M. ; Edwards-Johnson, J. ( January 2021 , The 4th FAccTRec Workshop on Responsible Recommendation at RecSys 2021)

   Most Fairness in AI research focuses on exposing biases in AI systems. A broader lens on fairness reveals that AI can serve a greater aspiration: rooting out societal inequities from their source. Specifically, we focus on inequities in health information, and aim to reduce bias in that domain using AI. The AI algorithms under the hood of search engines and social media, many of which are based on recommender systems, have an outsized impact on the quality of medical and health information online. Therefore, embedding bias detection and reduction into these recommender systems serving up medical and health content online could have an outsized positive impact on patient outcomes and wellbeing. In this position paper, we offer the following contributions: (1) we propose a novel framework of Fairness via AI, inspired by insights from medical education, sociology and antiracism; (2) we define a new term, bisinformation, which is related to, but distinct from, misinformation, and encourage researchers to study it; (3) we propose using AI to study, detect and mitigate biased, harmful, and/or false health information that disproportionately hurts minority groups in society; and (4) we suggest several pillars and pose several open problems in order to seed inquiry inthis new space. While part (3) of this work specifically focuses on the health domain, the fundamental computer science advances and contributions stemming from research efforts in bias reduction and Fairness via AI have broad implications in all areas of society. 

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2. Fairness via AI: Bias Reduction in Medical Information

   Dori-Hacohen, S. ; Montenegro, R. ; Murai, F. ; Hale, S. A. ; Sung, K. ; Blain, M. ; Edwards-Johnson, J. ( January 2021 , The 4th FAccTRec Workshop on Responsible Recommendation at RecSys 2021)

   Most Fairness in AI research focuses on exposing biases in AI systems. A broader lens on fairness reveals that AI can serve a greater aspiration: rooting out societal inequities from their source. Specifically, we focus on inequities in health information, and aim to reduce bias in that domain using AI. The AI algorithms under the hood of search engines and social media, many of which are based on recommender systems, have an outsized impact on the quality of medical and health information online. Therefore, embedding bias detection and reduction into these recommender systems serving up medical and health content online could have an outsized positive impact on patient outcomes and wellbeing. In this position paper, we offer the following contributions: (1) we propose a novel framework of Fairness via AI, inspired by insights from medical education, sociology and antiracism; (2) we define a new term, bisinformation, which is related to, but distinct from, misinformation, and encourage researchers to study it; (3) we propose using AI to study, detect and mitigate biased, harmful, and/or false health information that disproportionately hurts minority groups in society; and (4) we suggest several pillars and pose several open problems in order to seed inquiry inthis new space. While part (3) of this work specifically focuses on the health domain, the fundamental computer science advances and contributions stemming from research efforts in bias reduction and Fairness via AI have broad implications in all areas of society. 

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3. Hardware, Software, and Wetware Codesign Environment for Synthetic Biology

   https://doi.org/10.34133/2022/9794510  

   Oliveira, Samuel M. ; Densmore, Douglas ( January 2022 , BioDesign Research)

   Synthetic biology is the process of forward engineering living systems. These systems can be used to produce biobased materials, agriculture, medicine, and energy. One approach to designing these systems is to employ techniques from the design of embedded electronics. These techniques include abstraction, standards, modularity, automated design, and formal semantic models of computation. Together, these elements form the foundation of “biodesign automation,” where software, robotics, and microfluidic devices combine to create exciting biological systems of the future. This paper describes a “hardware, software, wetware” codesign vision where software tools can be made to act as “genetic compilers” that transform high-level specifications into engineered “genetic circuits” (wetware). This is followed by a process where automation equipment, well-defined experimental workflows, and microfluidic devices are explicitly designed to house, execute, and test these circuits (hardware). These systems can be used as either massively parallel experimental platforms or distributed bioremediation and biosensing devices. Next, scheduling and control algorithms (software) manage these systems’ actual execution and data analysis tasks. A distinguishing feature of this approach is how all three of these aspects (hardware, software, and wetware) may be derived from the same basic specification in parallel and generated to fulfill specific cost, performance, and structural requirements. 

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4. Path-Specific Counterfactual Fairness for Recommender Systems

   https://doi.org/10.1145/3580305.3599462  

   Zhu, Yaochen ; Ma, Jing ; Wu, Liang ; Guo, Qi ; Hong, Liangjie ; Li, Jundong ( August 2023 , Proceedings of the 29th ACM SIGKDD Conference on Knowledge Discovery and Data Mining)

   Recommender systems (RSs) have become an indispensable part of online platforms. With the growing concerns of algorithmic fairness, RSs are not only expected to deliver high-quality personalized content, but are also demanded not to discriminate against users based on their demographic information. However, existing RSs could capture undesirable correlations between sensitive features and observed user behaviors, leading to biased recommendations. Most fair RSs tackle this problem by completely blocking the influences of sensitive features on recommendations. But since sensitive features may also affect user interests in a fair manner (e.g., race on culture-based preferences), indiscriminately eliminating all the influences of sensitive features inevitably degenerate the recommendations quality and necessary diversities. To address this challenge, we propose a path-specific fair RS (PSF-RS) for recommendations. Specifically, we summarize all fair and unfair correlations between sensitive features and observed ratings into two latent proxy mediators, where the concept of path-specific bias (PS-Bias) is defined based on path-specific counterfactual inference. Inspired by Pearl's minimal change principle, we address the PS-Bias by minimally transforming the biased factual world into a hypothetically fair world, where a fair RS model can be learned accordingly by solving a constrained optimization problem. For the technical part, we propose a feasible implementation of PSF-RS, i.e., PSF-VAE, with weakly-supervised variational inference, which robustly infers the latent mediators such that unfairness can be mitigated while necessary recommendation diversities can be maximally preserved simultaneously. Experiments conducted on semi-simulated and real-world datasets demonstrate the effectiveness of PSF-RS. 

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5. SOSRepair: Expressive Semantic Search for Real-World Program Repair

   https://doi.org/10.1109/TSE.2019.2944914  

   Afzal, Afsoon ; Motwani, Manish ; Stolee, Kathryn ; Brun, Yuriy ; Le Goues, Claire ( January 2020 , IEEE Transactions on Software Engineering)

   Automated program repair holds the potential to significantly reduce software maintenance effort and cost. However, recent studies have shown that it often produces low-quality patches that repair some but break other functionality. We hypothesize that producing patches by replacing likely faulty regions of code with semantically-similar code fragments, and doing so at a higher level of granularity than prior approaches can better capture abstraction and the intended specification, and can improve repair quality. We create SOSRepair, an automated program repair technique that uses semantic code search to replace candidate buggy code regions with behaviorally-similar (but not identical) code written by humans. SOSRepair is the first such technique to scale to real-world defects in real-world systems. On a subset of the ManyBugs benchmark of such defects, SOSRepair produces patches for 23 (35%) of the 65 defects, including 3, 5, and 8 defects for which previous state-of-the-art techniques Angelix, Prophet, and GenProg do not, respectively. On these 23 defects, SOSRepair produces more patches (8, 35%) that pass all independent tests than the prior techniques. We demonstrate a relationship between patch granularity and the ability to produce patches that pass all independent tests. We then show that fault localization precision is a key factor in SOSRepair's success. Manually improving fault localization allows SOSRepair to patch 24 (37%) defects, of which 16 (67%) pass all independent tests. We conclude that (1) higher-granularity, semantic-based patches can improve patch quality, (2) semantic search is promising for producing high-quality real-world defect repairs, (3) research in fault localization can significantly improve the quality of program repair techniques, and (4) semi-automated approaches in which developers suggest fix locations may produce high-quality patches. 

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