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1. Detecting Adversarial Examples Using Data Manifolds

   Jha, Susmit ; Jang, Uyeong ; Jha, Somesh ; Jalaian, Brian ( January 2018 , MILCOM IEEE Military Communications Conference)

   Models produced by machine learning, particularly deep neural networks, are state-of-the-art for many machine learning tasks and demonstrate very high prediction accuracy. Unfortunately, these models are also very brittle and vulnerable to specially crafted adversarial examples. Recent results have shown that accuracy of these models can be reduced from close to hundred percent to below 5\% using adversarial examples. This brittleness of deep neural networks makes it challenging to deploy these learning models in security-critical areas where adversarial activity is expected, and cannot be ignored. A number of methods have been recently proposed to craft more effective and generalizable attacks on neural networks along with competing efforts to improve robustness of these learning models. But the current approaches to make machine learning techniques more resilient fall short of their goal. Further, the succession of new adversarial attacks against proposed methods to increase neural network robustness raises doubts about a foolproof approach to robustify machine learning models against all possible adversarial attacks. In this paper, we consider the problem of detecting adversarial examples. This would help identify when the learning models cannot be trusted without attempting to repair the models or make them robust to adversarial attacks. This goal of findingmore »limitations of the learning model presents a more tractable approach to protecting against adversarial attacks. Our approach is based on identifying a low dimensional manifold in which the training samples lie, and then using the distance of a new observation from this manifold to identify whether this data point is adversarial or not. Our empirical study demonstrates that adversarial examples not only lie farther away from the data manifold, but this distance from manifold of the adversarial examples increases with the attack confidence. Thus, adversarial examples that are likely to result into incorrect prediction by the machine learning model is also easier to detect by our approach. This is a first step towards formulating a novel approach based on computational geometry that can identify the limiting boundaries of a machine learning model, and detect adversarial attacks.« less
2. The Temple University Digital Pathology Corpus: The Breast Tissue Subset

   https://doi.org/10.1109/SPMB52430.2021.9672275  

   Wevodau, Z. ; Doshna, B. ; Jhala, N. ; Akhtar, I. ; Obeid, I. ; Picone, J. ( December 2021 , Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB))

   Obeid, I. (Ed.)

   The Neural Engineering Data Consortium (NEDC) is developing the Temple University Digital Pathology Corpus (TUDP), an open source database of high-resolution images from scanned pathology samples [1], as part of its National Science Foundation-funded Major Research Instrumentation grant titled “MRI: High Performance Digital Pathology Using Big Data and Machine Learning” [2]. The long-term goal of this project is to release one million images. We have currently scanned over 100,000 images and are in the process of annotating breast tissue data for our first official corpus release, v1.0.0. This release contains 3,505 annotated images of breast tissue including 74 patients with cancerous diagnoses (out of a total of 296 patients). In this poster, we will present an analysis of this corpus and discuss the challenges we have faced in efficiently producing high quality annotations of breast tissue. It is well known that state of the art algorithms in machine learning require vast amounts of data. Fields such as speech recognition [3], image recognition [4] and text processing [5] are able to deliver impressive performance with complex deep learning models because they have developed large corpora to support training of extremely high-dimensional models (e.g., billions of parameters). Other fields that do notmore »have access to such data resources must rely on techniques in which existing models can be adapted to new datasets [6]. A preliminary version of this breast corpus release was tested in a pilot study using a baseline machine learning system, ResNet18 [7], that leverages several open-source Python tools. The pilot corpus was divided into three sets: train, development, and evaluation. Portions of these slides were manually annotated [1] using the nine labels in Table 1 [8] to identify five to ten examples of pathological features on each slide. Not every pathological feature is annotated, meaning excluded areas can include focuses particular to these labels that are not used for training. A summary of the number of patches within each label is given in Table 2. To maintain a balanced training set, 1,000 patches of each label were used to train the machine learning model. Throughout all sets, only annotated patches were involved in model development. The performance of this model in identifying all the patches in the evaluation set can be seen in the confusion matrix of classification accuracy in Table 3. The highest performing labels were background, 97% correct identification, and artifact, 76% correct identification. A correlation exists between labels with more than 6,000 development patches and accurate performance on the evaluation set. Additionally, these results indicated a need to further refine the annotation of invasive ductal carcinoma (“indc”), inflammation (“infl”), nonneoplastic features (“nneo”), normal (“norm”) and suspicious (“susp”). This pilot experiment motivated changes to the corpus that will be discussed in detail in this poster presentation. To increase the accuracy of the machine learning model, we modified how we addressed underperforming labels. One common source of error arose with how non-background labels were converted into patches. Large areas of background within other labels were isolated within a patch resulting in connective tissue misrepresenting a non-background label. In response, the annotation overlay margins were revised to exclude benign connective tissue in non-background labels. Corresponding patient reports and supporting immunohistochemical stains further guided annotation reviews. The microscopic diagnoses given by the primary pathologist in these reports detail the pathological findings within each tissue site, but not within each specific slide. The microscopic diagnoses informed revisions specifically targeting annotated regions classified as cancerous, ensuring that the labels “indc” and “dcis” were used only in situations where a micropathologist diagnosed it as such. Further differentiation of cancerous and precancerous labels, as well as the location of their focus on a slide, could be accomplished with supplemental immunohistochemically (IHC) stained slides. When distinguishing whether a focus is a nonneoplastic feature versus a cancerous growth, pathologists employ antigen targeting stains to the tissue in question to confirm the diagnosis. For example, a nonneoplastic feature of usual ductal hyperplasia will display diffuse staining for cytokeratin 5 (CK5) and no diffuse staining for estrogen receptor (ER), while a cancerous growth of ductal carcinoma in situ will have negative or focally positive staining for CK5 and diffuse staining for ER [9]. Many tissue samples contain cancerous and non-cancerous features with morphological overlaps that cause variability between annotators. The informative fields IHC slides provide could play an integral role in machine model pathology diagnostics. Following the revisions made on all the annotations, a second experiment was run using ResNet18. Compared to the pilot study, an increase of model prediction accuracy was seen for the labels indc, infl, nneo, norm, and null. This increase is correlated with an increase in annotated area and annotation accuracy. Model performance in identifying the suspicious label decreased by 25% due to the decrease of 57% in the total annotated area described by this label. A summary of the model performance is given in Table 4, which shows the new prediction accuracy and the absolute change in error rate compared to Table 3. The breast tissue subset we are developing includes 3,505 annotated breast pathology slides from 296 patients. The average size of a scanned SVS file is 363 MB. The annotations are stored in an XML format. A CSV version of the annotation file is also available which provides a flat, or simple, annotation that is easy for machine learning researchers to access and interface to their systems. Each patient is identified by an anonymized medical reference number. Within each patient’s directory, one or more sessions are identified, also anonymized to the first of the month in which the sample was taken. These sessions are broken into groupings of tissue taken on that date (in this case, breast tissue). A deidentified patient report stored as a flat text file is also available. Within these slides there are a total of 16,971 total annotated regions with an average of 4.84 annotations per slide. Among those annotations, 8,035 are non-cancerous (normal, background, null, and artifact,) 6,222 are carcinogenic signs (inflammation, nonneoplastic and suspicious,) and 2,714 are cancerous labels (ductal carcinoma in situ and invasive ductal carcinoma in situ.) The individual patients are split up into three sets: train, development, and evaluation. Of the 74 cancerous patients, 20 were allotted for both the development and evaluation sets, while the remain 34 were allotted for train. The remaining 222 patients were split up to preserve the overall distribution of labels within the corpus. This was done in hope of creating control sets for comparable studies. Overall, the development and evaluation sets each have 80 patients, while the training set has 136 patients. In a related component of this project, slides from the Fox Chase Cancer Center (FCCC) Biosample Repository (https://www.foxchase.org/research/facilities/genetic-research-facilities/biosample-repository -facility) are being digitized in addition to slides provided by Temple University Hospital. This data includes 18 different types of tissue including approximately 38.5% urinary tissue and 16.5% gynecological tissue. These slides and the metadata provided with them are already anonymized and include diagnoses in a spreadsheet with sample and patient ID. We plan to release over 13,000 unannotated slides from the FCCC Corpus simultaneously with v1.0.0 of TUDP. Details of this release will also be discussed in this poster. Few digitally annotated databases of pathology samples like TUDP exist due to the extensive data collection and processing required. The breast corpus subset should be released by November 2021. By December 2021 we should also release the unannotated FCCC data. We are currently annotating urinary tract data as well. We expect to release about 5,600 processed TUH slides in this subset. We have an additional 53,000 unprocessed TUH slides digitized. Corpora of this size will stimulate the development of a new generation of deep learning technology. In clinical settings where resources are limited, an assistive diagnoses model could support pathologists’ workload and even help prioritize suspected cancerous cases. ACKNOWLEDGMENTS This material is supported by the National Science Foundation under grants nos. CNS-1726188 and 1925494. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. REFERENCES [1] N. Shawki et al., “The Temple University Digital Pathology Corpus,” in Signal Processing in Medicine and Biology: Emerging Trends in Research and Applications, 1st ed., I. Obeid, I. Selesnick, and J. Picone, Eds. New York City, New York, USA: Springer, 2020, pp. 67 104. https://www.springer.com/gp/book/9783030368432. [2] J. Picone, T. Farkas, I. Obeid, and Y. Persidsky, “MRI: High Performance Digital Pathology Using Big Data and Machine Learning.” Major Research Instrumentation (MRI), Division of Computer and Network Systems, Award No. 1726188, January 1, 2018 – December 31, 2021. https://www. isip.piconepress.com/projects/nsf_dpath/. [3] A. Gulati et al., “Conformer: Convolution-augmented Transformer for Speech Recognition,” in Proceedings of the Annual Conference of the International Speech Communication Association (INTERSPEECH), 2020, pp. 5036-5040. https://doi.org/10.21437/interspeech.2020-3015. [4] C.-J. Wu et al., “Machine Learning at Facebook: Understanding Inference at the Edge,” in Proceedings of the IEEE International Symposium on High Performance Computer Architecture (HPCA), 2019, pp. 331–344. https://ieeexplore.ieee.org/document/8675201. [5] I. Caswell and B. Liang, “Recent Advances in Google Translate,” Google AI Blog: The latest from Google Research, 2020. [Online]. Available: https://ai.googleblog.com/2020/06/recent-advances-in-google-translate.html. [Accessed: 01-Aug-2021]. [6] V. Khalkhali, N. Shawki, V. Shah, M. Golmohammadi, I. Obeid, and J. Picone, “Low Latency Real-Time Seizure Detection Using Transfer Deep Learning,” in Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB), 2021, pp. 1 7. https://www.isip. piconepress.com/publications/conference_proceedings/2021/ieee_spmb/eeg_transfer_learning/. [7] J. Picone, T. Farkas, I. Obeid, and Y. Persidsky, “MRI: High Performance Digital Pathology Using Big Data and Machine Learning,” Philadelphia, Pennsylvania, USA, 2020. https://www.isip.piconepress.com/publications/reports/2020/nsf/mri_dpath/. [8] I. Hunt, S. Husain, J. Simons, I. Obeid, and J. Picone, “Recent Advances in the Temple University Digital Pathology Corpus,” in Proceedings of the IEEE Signal Processing in Medicine and Biology Symposium (SPMB), 2019, pp. 1–4. https://ieeexplore.ieee.org/document/9037859. [9] A. P. Martinez, C. Cohen, K. Z. Hanley, and X. (Bill) Li, “Estrogen Receptor and Cytokeratin 5 Are Reliable Markers to Separate Usual Ductal Hyperplasia From Atypical Ductal Hyperplasia and Low-Grade Ductal Carcinoma In Situ,” Arch. Pathol. Lab. Med., vol. 140, no. 7, pp. 686–689, Apr. 2016. https://doi.org/10.5858/arpa.2015-0238-OA.« less
3. Near real-time ASL recognition using a millimeter wave radar

   https://doi.org/10.1117/12.2588616  

   Adeoluwa, Oladipupo ; Kearney, Sean J. ; Kurtoglu, Emre ; Connors, Charles ; Gurbuz, Sevgi Zubeyde ( April 2021 , Proceedings of SPIE (International Society of Optics and Photonics))

   Raynal, Ann M. ; Ranney, Kenneth I. (Ed.)

   Most research in technologies for the Deaf community have focused on translation using either video or wearable devices. Sensor-augmented gloves have been reported to yield higher gesture recognition rates than camera-based systems; however, they cannot capture information expressed through head and body movement. Gloves are also intrusive and inhibit users in their pursuit of normal daily life, while cameras can raise concerns over privacy and are ineffective in the dark. In contrast, RF sensors are non-contact, non-invasive and do not reveal private information even if hacked. Although RF sensors are unable to measure facial expressions or hand shapes, which would be required for complete translation, this paper aims to exploit near real-time ASL recognition using RF sensors for the design of smart Deaf spaces. In this way, we hope to enable the Deaf community to benefit from advances in technologies that could generate tangible improvements in their quality of life. More specifically, this paper investigates near real-time implementation of machine learning and deep learning architectures for the purpose of sequential ASL signing recognition. We utilize a 60 GHz RF sensor which transmits a frequency modulation continuous wave (FMWC waveform). RF sensors can acquire a unique source of information that ismore »inaccessible to optical or wearable devices: namely, a visual representation of the kinematic patterns of motion via the micro-Doppler signature. Micro-Doppler refers to frequency modulations that appear about the central Doppler shift, which are caused by rotational or vibrational motions that deviate from principle translational motion. In prior work, we showed that fractal complexity computed from RF data could be used to discriminate signing from daily activities and that RF data could reveal linguistic properties, such as coarticulation. We have also shown that machine learning can be used to discriminate with 99% accuracy the signing of native Deaf ASL users from that of copysigning (or imitation signing) by hearing individuals. Therefore, imitation signing data is not effective for directly training deep models. But, adversarial learning can be used to transform imitation signing to resemble native signing, or, alternatively, physics-aware generative models can be used to synthesize ASL micro-Doppler signatures for training deep neural networks. With such approaches, we have achieved over 90% recognition accuracy of 20 ASL signs. In natural environments, however, near real-time implementations of classification algorithms are required, as well as an ability to process data streams in a continuous and sequential fashion. In this work, we focus on extensions of our prior work towards this aim, and compare the efficacy of various approaches for embedding deep neural networks (DNNs) on platforms such as a Raspberry Pi or Jetson board. We examine methods for optimizing the size and computational complexity of DNNs for embedded micro-Doppler analysis, methods for network compression, and their resulting sequential ASL recognition performance.« less
4. Origin: Enabling On-Device Intelligence for Human Activity Recognition Using Energy Harvesting Wireless Sensor Networks

   https://doi.org/10.23919/DATE51398.2021.9474017  

   Mishra, Cyan Subhra ; Sampson, Jack ; Kandemir, Mahmut Taylan ; Narayanan, Vijaykrishnan ( February 2021 , 2021 Design, Automation & Test in Europe Conference & Exhibition (DATE))

   There is an increasing demand for performing machine learning tasks, such as human activity recognition (HAR) on emerging ultra-low-power internet of things (IoT) platforms. Recent works show substantial efficiency boosts from performing inference tasks directly on the IoT nodes rather than merely transmitting raw sensor data. However, the computation and power demands of deep neural network (DNN) based inference pose significant challenges when executed on the nodes of an energy-harvesting wireless sensor network (EH-WSN). Moreover, managing inferences requiring responses from multiple energy-harvesting nodes imposes challenges at the system level in addition to the constraints at each node. This paper presents a novel scheduling policy along with an adaptive ensemble learner to efficiently perform HAR on a distributed energy-harvesting body area network. Our proposed policy, Origin, strategically ensures efficient and accurate individual inference execution at each sensor node by using a novel activity-aware scheduling approach. It also leverages the continuous nature of human activity when coordinating and aggregating results from all the sensor nodes to improve final classification accuracy. Further, Origin proposes an adaptive ensemble learner to personalize the optimizations based on each individual user. Experimental results using two different HAR data-sets show Origin, while running on harvested energy, to bemore »at least 2.5% more accurate than a classical battery-powered energy aware HAR classifier continuously operating at the same average power.« less
5. w-HAR: An Activity Recognition Dataset and Framework Using Low-Power Wearable Devices

   https://doi.org/10.3390/s20185356  

   Bhat, Ganapati ; Tran, Nicholas ; Shill, Holly ; Ogras, Umit Y. ( September 2020 , Sensors)

   Human activity recognition (HAR) is growing in popularity due to its wide-ranging applications in patient rehabilitation and movement disorders. HAR approaches typically start with collecting sensor data for the activities under consideration and then develop algorithms using the dataset. As such, the success of algorithms for HAR depends on the availability and quality of datasets. Most of the existing work on HAR uses data from inertial sensors on wearable devices or smartphones to design HAR algorithms. However, inertial sensors exhibit high noise that makes it difficult to segment the data and classify the activities. Furthermore, existing approaches typically do not make their data available publicly, which makes it difficult or impossible to obtain comparisons of HAR approaches. To address these issues, we present wearable HAR (w-HAR) which contains labeled data of seven activities from 22 users. Our dataset’s unique aspect is the integration of data from inertial and wearable stretch sensors, thus providing two modalities of activity information. The wearable stretch sensor data allows us to create variable-length segment data and ensure that each segment contains a single activity. We also provide a HAR framework to use w-HAR to classify the activities. To this end, we first perform a designmore »space exploration to choose a neural network architecture for activity classification. Then, we use two online learning algorithms to adapt the classifier to users whose data are not included at design time. Experiments on the w-HAR dataset show that our framework achieves 95% accuracy while the online learning algorithms improve the accuracy by as much as 40%.« less