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Title: Squaramide Organocatalyzed Addition of a Masked Acyl Cyanide to β-Nitrostyrenes
A method for the squaramide-organocatalyzed enantioselective addition of a silyl-protected masked acyl cyanide (MAC) reagent to various β-nitrostyrenes is described. Reactions are carried out in a freezer and provide products cleanly and in high enantioselectivities at very low catalyst loadings. Adducts are then unmasked, providing various oxidation state 3 functional groups, thereby highlighting the utility of these MAC reagents and a new strategy for the preparation of β-amino acids.  more » « less
Award ID(s):
1848257
PAR ID:
10502895
Author(s) / Creator(s):
; ; ; ;
Publisher / Repository:
American Chemical Society
Date Published:
Journal Name:
The Journal of Organic Chemistry
Volume:
88
Issue:
23
ISSN:
0022-3263
Page Range / eLocation ID:
16666 to 16670
Format(s):
Medium: X
Sponsoring Org:
National Science Foundation
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