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1. Simulating human behavioral changes in livestock production systems during an epidemic: The case of the US beef cattle industry

   https://doi.org/10.1371/journal.pone.0253498  

   Yang, Qihui; Gruenbacher, Don M.; Brase, Gary L.; Heier Stamm, Jessica L.; DeLoach, Scott A.; Scoglio, Caterina M. (June 2021, PLOS ONE)

   Woźniakowski, Grzegorz (Ed.)

   Human behavioral change around biosecurity in response to increased awareness of disease risks is a critical factor in modeling animal disease dynamics. Here, biosecurity is referred to as implementing control measures to decrease the chance of animal disease spreading. However, social dynamics are largely ignored in traditional livestock disease models. Not accounting for these dynamics may lead to substantial bias in the predicted epidemic trajectory. In this research, an agent-based model is developed by integrating the human decision-making process into epidemiological processes. We simulate human behavioral change on biosecurity practices following an increase in the regional disease incidence. We apply the model to beef cattle production systems in southwest Kansas, United States, to examine the impact of human behavior factors on a hypothetical foot-and-mouth disease outbreak. The simulation results indicate that heterogeneity of individuals regarding risk attitudes significantly affects the epidemic dynamics, and human-behavior factors need to be considered for improved epidemic forecasting. With the same initial biosecurity status, increasing the percentage of risk-averse producers in the total population using a targeted strategy can more effectively reduce the number of infected producer locations and cattle losses compared to a random strategy. In addition, the reduction in epidemic size caused by the shifting of producers’ risk attitudes towards risk-aversion is heavily dependent on the initial biosecurity level. A comprehensive investigation of the initial biosecurity status is recommended to inform risk communication strategy design. 

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2. Adaptive human behavior and delays in information availability autonomously modulate epidemic waves

   https://doi.org/10.1093/pnasnexus/pgaf145  

   Mahmud, Md_Shahriar; Eshun, Solomon; Espinoza, Baltazar; Kadelka, Claus; Arenas, ed., Alex (May 2025, PNAS Nexus)

   Abstract The recurrence of epidemic waves has been a hallmark of infectious disease outbreaks. Repeated surges in infections pose significant challenges to public health systems, yet the mechanisms that drive these waves remain insufficiently understood. Most prior models attribute epidemic waves to exogenous factors, such as transmission seasonality, viral mutations, or implementation of public health interventions. We show that epidemic waves can emerge autonomously from the feedback loop between infection dynamics and human behavior. Our results are based on a behavioral framework in which individuals continuously adjust their level of risk mitigation subject to their perceived risk of infection, which depends on information availability and disease severity. We show that delayed behavioral responses alone can lead to the emergence of multiple epidemic waves. The magnitude and frequency of these waves depend on the interplay between behavioral factors (delay, severity, and sensitivity of responses) and disease factors (transmission and recovery rates). Notably, if the response is either too prompt or excessively delayed, multiple waves cannot emerge. Our results further align with previous observations that adaptive human behavior can produce nonmonotonic final epidemic sizes, shaped by the trade-offs between various biological and behavioral factors—namely, risk sensitivity, response stringency, and disease generation time. Interestingly, we found that the minimal final epidemic size occurs on regimes that exhibit a few damped oscillations. Altogether, our results emphasize the importance of integrating social and operational factors into infectious disease models, in order to capture the joint evolution of adaptive behavioral responses and epidemic dynamics. 

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3. Parameter estimation in behavioral epidemic models with endogenous societal risk-response

   https://doi.org/10.1371/journal.pcbi.1011992  

   Osi, Ann; Ghaffarzadegan, Navid (March 2024, PLOS Computational Biology)

   Struchiner, Claudio José (Ed.)

   Behavioral epidemic models incorporating endogenous societal risk-response, where changes in risk perceptions prompt adjustments in contact rates, are crucial for predicting pandemic trajectories. Accurate parameter estimation in these models is vital for validation and precise projections. However, few studies have examined the problem of identifiability in models where disease and behavior parameters must be jointly estimated. To address this gap, we conduct simulation experiments to assess the effect on parameter estimation accuracy of a) delayed risk response, b) neglecting behavioral response in model structure, and c) integrating disease and public behavior data. Our findings reveal systematic biases in estimating behavior parameters even with comprehensive and accurate disease data and a well-structured simulation model when data are limited to the first wave. This is due to the significant delay between evolving risks and societal reactions, corresponding to the duration of a pandemic wave. Moreover, we demonstrate that conventional SEIR models, which disregard behavioral changes, may fit well in the early stages of a pandemic but exhibit significant errors after the initial peak. Furthermore, early on, relatively small data samples of public behavior, such as mobility, can significantly improve estimation accuracy. However, the marginal benefits decline as the pandemic progresses. These results highlight the challenges associated with the joint estimation of disease and behavior parameters in a behavioral epidemic model. 

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4. Mathematical analysis of simple behavioral epidemic models

   https://doi.org/10.1016/j.mbs.2024.109250  

   LeJeune, Leah; Ghaffarzadegan, Navid; Childs, Lauren M; Saucedo, Omar (September 2024, Mathematical Biosciences)

   COVID-19 highlighted the importance of considering human behavior change when modeling disease dynamics. This led to developing various models that incorporate human behavior. Our objective is to contribute to an in-depth, mathematical examination of such models. Here, we consider a simple deterministic compartmental model with endogenous incorporation of human behavior (i.e., behavioral feedback) through transmission in a classic Susceptible–Exposed–Infectious–Recovered (SEIR) structure. Despite its simplicity, the SEIR structure with behavior (SEIRb) was shown to perform well in forecasting, especially compared to more complicated models. We contrast this model with an SEIR model that excludes endogenous incorporation of behavior. Both models assume permanent immunity to COVID-19, so we also consider a modification of the models which include waning immunity (SEIRS and SEIRSb). We perform equilibria, sensitivity, and identifiability analyses on all models and examine the fidelity of the models to replicate COVID-19 data across the United States. Endogenous incorporation of behavior significantly improves a model’s ability to produce realistic outbreaks. While the two endogenous models are similar with respect to identifiability and sensitivity, the SEIRSb model, with the more accurate assumption of the waning immunity, strengthens the initial SEIRb model by allowing for the existence of an endemic equilibrium, a realistic feature of COVID-19 dynamics. When fitting the model to data, we further consider the addition of simple seasonality affecting disease transmission to highlight the explanatory power of the models. 

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5. Social divisions and risk perception drive divergent epidemics and large later waves

   https://doi.org/10.1017/ehs.2023.2  

   Harris, Mallory J.; Cardenas, Kimberly J.; Mordecai, Erin A. (January 2023, Evolutionary Human Sciences)

   Abstract During infectious disease outbreaks, individuals may adopt protective measures like vaccination and physical distancing in response to awareness of disease burden. Prior work showed how feedbacks between epidemic intensity and awareness-based behaviour shape disease dynamics. These models often overlook social divisions, where population subgroups may be disproportionately impacted by a disease and more responsive to the effects of disease within their group. We develop a compartmental model of disease transmission and awareness-based protective behaviour in a population split into two groups to explore the impacts of awareness separation (relatively greater in- vs. out-group awareness of epidemic severity) and mixing separation (relatively greater in- vs. out-group contact rates). Using simulations, we show that groups that are more separated in awareness have smaller differences in mortality. Fatigue (i.e. abandonment of protective measures over time) can drive additional infection waves that can even exceed the size of the initial wave, particularly if uniform awareness drives early protection in one group, leaving that group largely susceptible to future infection. Counterintuitively, vaccine or infection-acquired immunity that is more protective against transmission and mortality may indirectly lead to more infections by reducing perceived risk of infection and therefore vaccine uptake. Awareness-based protective behaviour, including awareness separation, can fundamentally alter disease dynamics. Social media summary: Depending on group division, behaviour based on perceived risk can change epidemic dynamics & produce large later waves. 

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