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Abstract AimsMyocardial infarction and heart failure are major cardiovascular diseases that affect millions of people in the USA with morbidity and mortality being highest among patients who develop cardiogenic shock. Early recognition of cardiogenic shock allows prompt implementation of treatment measures. Our objective is to develop a new dynamic risk score, called CShock, to improve early detection of cardiogenic shock in the cardiac intensive care unit (ICU). Methods and resultsWe developed and externally validated a deep learning-based risk stratification tool, called CShock, for patients admitted into the cardiac ICU with acute decompensated heart failure and/or myocardial infarction to predict the onset of cardiogenic shock. We prepared a cardiac ICU dataset using the Medical Information Mart for Intensive Care-III database by annotating with physician-adjudicated outcomes. This dataset which consisted of 1500 patients with 204 having cardiogenic/mixed shock was then used to train CShock. The features used to train the model for CShock included patient demographics, cardiac ICU admission diagnoses, routinely measured laboratory values and vital signs, and relevant features manually extracted from echocardiogram and left heart catheterization reports. We externally validated the risk model on the New York University (NYU) Langone Health cardiac ICU database which was also annotated with physician-adjudicated outcomes. The external validation cohort consisted of 131 patients with 25 patients experiencing cardiogenic/mixed shock. CShock achieved an area under the receiver operator characteristic curve (AUROC) of 0.821 (95% CI 0.792–0.850). CShock was externally validated in the more contemporary NYU cohort and achieved an AUROC of 0.800 (95% CI 0.717–0.884), demonstrating its generalizability in other cardiac ICUs. Having an elevated heart rate is most predictive of cardiogenic shock development based on Shapley values. The other top 10 predictors are having an admission diagnosis of myocardial infarction with ST-segment elevation, having an admission diagnosis of acute decompensated heart failure, Braden Scale, Glasgow Coma Scale, blood urea nitrogen, systolic blood pressure, serum chloride, serum sodium, and arterial blood pH. ConclusionThe novel CShock score has the potential to provide automated detection and early warning for cardiogenic shock and improve the outcomes for millions of patients who suffer from myocardial infarction and heart failure.
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Machine learning-enabled screening for aortic stenosis with handheld ultrasound
Aims: Neural network classifiers can detect aortic stenosis (AS) using limited cardiac ultrasound images. While networks perform very well using cart-based imaging, they have never been tested or fine-tuned for use with focused cardiac ultrasound (FoCUS) acquisitions obtained on handheld ultrasound devices. Methods and results: Prospective study performed at Tufts Medical Center. All patients ≥65 years of age referred for clinically indicated transthoracic echocardigraphy (TTE) were eligible for inclusion. Parasternal long axis and parasternal short axis imaging was acquired using a commercially available handheld ultrasound device. Our cart-based AS classifier (trained on ∼10 000 images) was tested on FoCUS imaging from 160 patients. The median age was 74 (inter-quartile range 69–80) years, 50% of patients were women. Thirty patients (18.8%) had some degree of AS. The area under the received operator curve (AUROC) of the cart-based model for detecting AS was 0.87 (95% CI 0.75–0.99) on the FoCUS test set. Last-layer fine-tuning on handheld data established a classifier with AUROC of 0.94 (0.91–0.97). AUROC during temporal external validation was 0.97 (95% CI 0.89–1.0). When performance of the fine-tuned AS classifier was modelled on potential screening environments (2 and 10% AS prevalence), the positive predictive value ranged from 0.72 (0.69–0.76) to 0.88 (0.81–0.97) and negative predictive value ranged from 0.94 (0.94–0.94) to 0.99 (0.99–0.99) respectively. Conclusion: Our cart-based machine-learning model for AS showed a drop in performance when tested on handheld ultrasound imaging collected by sonographers. Fine-tuning the AS classifier improved performance and demonstrates potential as a novel approach to detecting AS through automated interpretation of handheld imaging.
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- Award ID(s):
- 2338962
- PAR ID:
- 10591808
- Publisher / Repository:
- Oxford University Press
- Date Published:
- Journal Name:
- European Heart Journal - Imaging Methods and Practice
- Volume:
- 3
- Issue:
- 1
- ISSN:
- 2755-9637
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript
- Journal Article:
- https://doi.org/10.1093/ehjimp/qyaf051
