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ABSTRACT Individualized modeling has become increasingly popular in recent years with its growing application in fields such as personalized medicine and mobile health studies. With rich longitudinal measurements, it is of great interest to model certain subject‐specific time‐varying covariate effects. In this paper, we propose an individualized time‐varying nonparametric model by leveraging the subgroup information from the population. The proposed method approximates the time‐varying covariate effect using nonparametric B‐splines and aggregates the estimated nonparametric coefficients that share common patterns. Moreover, the proposed method can effectively handle various missing data patterns that frequently arise in mobile health data. Specifically, our method achieves subgrouping by flexibly accommodating varying dimensions of B‐spline coefficients due to missingness. This capability sets it apart from other fusion‐type approaches for subgrouping. The subgroup information can also potentially provide meaningful insight into the characteristics of subjects and assist in recommending an effective treatment or intervention. An efficient ADMM algorithm is developed for implementation. Our numerical studies and application to mobile health data on monitoring pregnant women's deep sleep and physical activities demonstrate that the proposed method achieves better performance compared to other existing methods.
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Individualized dynamic latent factor model for multi-resolutional data with application to mobile health
Summary Mobile health has emerged as a major success for tracking individual health status, due to the popularity and power of smartphones and wearable devices. This has also brought great challenges in handling heterogeneous, multi-resolution data that arise ubiquitously in mobile health due to irregular multivariate measurements collected from individuals. In this paper, we propose an individualized dynamic latent factor model for irregular multi-resolution time series data to interpolate unsampled measurements of time series with low resolution. One major advantage of the proposed method is the capability to integrate multiple irregular time series and multiple subjects by mapping the multi-resolution data to the latent space. In addition, the proposed individualized dynamic latent factor model is applicable to capturing heterogeneous longitudinal information through individualized dynamic latent factors. Our theory provides a bound on the integrated interpolation error and the convergence rate for B-spline approximation methods. Both the simulation studies and the application to smartwatch data demonstrate the superior performance of the proposed method compared to existing methods.
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- Award ID(s):
- 2210640
- PAR ID:
- 10608245
- Publisher / Repository:
- Oxford University Press
- Date Published:
- Journal Name:
- Biometrika
- Volume:
- 111
- Issue:
- 4
- ISSN:
- 0006-3444
- Page Range / eLocation ID:
- 1257 to 1275
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.1093/biomet/asae015
