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1. Silver(II) and Silver(III) Intermediates in Alkene Aziridination with a Dinuclear Silver(I) Nitrene Transfer Catalyst

   https://doi.org/10.1021/acscatal.0c00065  

   Elkoush, Tasneem; Mak, Choi L.; Paley, Daniel W.; Campbell, Michael G. (April 2020, ACS Catalysis)
2. Emerging investigator series: characterization of silver and silver nanoparticle interactions with zinc finger peptides

   https://doi.org/10.1039/C9EN00065H  

   Park, Grace; Amaris, Zoe N.; Eiken, Madeline K.; Baumgartner, Karl V.; Johnston, Kathryn A.; Williams, Mari A.; Marckwordt, Jasmine G.; Millstone, Jill E.; Splan, Kathryn E.; Wheeler, Korin E. (January 2019, Environmental Science: Nano)

   In biological systems, chemical and physical transformations of engineered silver nanomaterials (AgENMs) are mediated, in part, by proteins and other biomolecules. Metalloprotein interactions with AgENMs are also central in understanding toxicity, antimicrobial, and resistance mechanisms. Despite their readily available thiolate and amine ligands, zinc finger (ZF) peptides have thus far escaped study in reaction with AgENMs and their Ag( i ) oxidative dissolution product. We report spectroscopic studies that characterize AgENM and Ag( i ) interactions with two ZF peptides that differ in sequence, but not in metal binding ligands: the ZF consensus peptide CP-CCHC and the C-terminal zinc finger domain of HIV-1 nucleocapsid protein p7 (NCp7_C). Both ZF peptides catalyze AgENM (10 and 40 nm, citrate coated) dissolution and agglomeration, two important AgENM transformations that impact bioreactivity. AgENMs and their oxidative dissolution product, Ag( i )(aq), mediate changes to ZF peptide structure and metalation as well. Spectroscopic titrations of Ag( i ) into apo-ZF peptides show an Ag( i )–thiolate charge transfer band, indicative of Ag( i )–ZF binding. Fluorescence studies of the Zn( ii )–NCp_7 complex indicate that the Ag( i ) also effectively competes with the Zn( ii ) to drive Zn( ii ) displacement from the ZFs. Upon interaction with AgENMs, Zn( ii ) bound ZF peptides show a secondary structural change in circular dichroism spectroscopy toward an apo-like structure. The results suggest that Ag( i ) and AgENMs may alter ZF protein function within the cell. 

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3. Tug-of-War between DNA Chelation and Silver Agglomeration in DNA–Silver Cluster Chromophores

   https://doi.org/10.1021/acs.jpcb.2c01054  

   Petty, Jeffrey T.; Lewis, David; Carnahan, Savannah; Kim, Dahye; Couch, Caroline (June 2022, The Journal of Physical Chemistry B)
4. Legionella pneumophila inactivation potency of silver nanoparticles and ionic silver and copper enhanced with microwave radiation

   Ayres, C.; Saleh, N. B.; Kirisits, M. J.; Lawler, D. F. (November 2019, 8th Sustainable Nanotechnology Organization Conference)

   Legionella pneumophila is a virulent bacterial pathogen that can cause a severe and deadly form of pneumonia called Legionnaires’ disease. Risk of infection increases when L. pneumophila are harbored inside free-living amoebae, which are resistant to traditional disinfection processes but lyse upon heat exposure. This project aims to develop a point-of-use technology based on microwave (MW) radiation and nanomaterial (e.g., silver, copper oxide, carbon nanotubes) exposure for L. pneumophila control. In this alternative technology, we hypothesize that amoebae will be lysed via localized interfacial heating, and the released L. pneumophila will be inactivated subsequently by heat, metal ions (from nanoparticle dissolution), and reactive oxygen species (ROS) produced in the process. The synergistic effect of microwaves and silver nanoparticles for enhanced, rapid inactivation has been demonstrated for Escherichia coli and planktonic L. pneumophila. Inactivation greater than 3-logs of each species has been achieved when subjected to silver nanoparticles (2-5 mg/L) and MW (2,450 MHz; 70 W) radiation. A mechanistic study using E. coli has determined the dominant interaction to be between released ions and MW radiation. Ultimately, the nanomaterials will be immobilized on a plaster of Paris or ceramic surface for flow through applications where both amoeba lysing and L. pneumophila inactivation will be achieved. 

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5. The Silver Lining

   Keahey, K. (August 2020, IEEE internet computing)

   Clouds are shareable scientific instruments that create the potential for reproducibility by ensuring that all investigators have access to a common execution platform on which computational experiments can be repeated and compared. By virtue of the interface they present, they also lead to the creation of digital artifacts compatible with the cloud, such as images or orchestration templates, that go a long way—and sometimes all the way—to representing an experiment in a digital, repeatable form. In this article, I describe how we developed these natural advantages of clouds in the Chameleon testbed and argue that we should leverage them to create a digital research marketplace that would make repeating experiments as natural and viable part of research as sharing ideas via reading papers is today. 

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