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Title: Variational Covariance Smoothing for Dynamic Functional Connectivity Analysis
Functional connectivity is among the widely used metrics to assess the network-level attributes of brain function. While most existing analysis frameworks assume static functional connectivity during the course of an experiment, to capture neural dynamics over short time scales, a time-varying notion of functional connectivity is required. By revealing how neural networks reconfigure in response to changing external stimuli, internal states, and task demands, time-varying functional connectivity can be leveraged to study flexible cognition, such as working memory, attention, and decision-making. A major challenge in estimating time-varying functional connectivity from high-dimensional neural is the associated computational complexity. Existing methods trade off accuracy for computational efficiency, especially in applications that require real-time or near real-time processing. Here, we build on existing work using covariance-domain state-space models and introduce a framework based on variational inference that allows low-complexity estimation of time-varying functional connectivity and construction of confidence intervals. We validate the performance of the proposed method using simulation studies. Our results reveal significant gains in computational complexity compared to existing methods, while maintaining high accuracy.  more » « less
Award ID(s):
2032649 2020624
PAR ID:
10656775
Author(s) / Creator(s):
 ;  ;  
Publisher / Repository:
IEEE
Date Published:
Page Range / eLocation ID:
245 to 249
Format(s):
Medium: X
Location:
2024 58th Asilomar Conference on Signals, Systems, and Computers, Pacific Grove, CA
Sponsoring Org:
National Science Foundation
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