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Unsupervised domain adaptation for semantic segmentation has been intensively studied due to the low cost of the pixel-level annotation for synthetic data. The most common approaches try to generate images or features mimicking the distribution in the target domain while preserving the semantic contents in the source domain so that a model can be trained with annotations from the latter. However, such methods highly rely on an image translator or feature extractor trained in an elaborated mechanism including adversarial training, which brings in extra complexity and instability in the adaptation process. Furthermore, these methods mainly focus on taking advantage of the labeled source dataset, leaving the unlabeled target dataset not fully utilized. In this paper, we propose a bidirectional style-induced domain adaptation method, called BiSIDA, that employs consistency regularization to efficiently exploit information from the unlabeled target domain dataset, requiring only a simple neural style transfer model. BiSIDA aligns domains by not only transferring source images into the style of target images but also transferring target images into the style of source images to perform high-dimensional perturbation on the unlabeled target images, which is crucial to the success in applying consistency regularization in segmentation tasks. Extensive experiments show that our BiSIDA achieves new state-of-the-art on two commonly-used synthetic-to-real domain adaptation benchmarks: GTA5-to-CityScapes and SYNTHIA-to-CityScapes. Code and pretrained style transfer model are available at: https://github.com/wangkaihong/BiSIDA.
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Reducing Domain Gap with Diffusion-Based Domain Adaptation for Cell Counting
Abstract—Generating realistic synthetic microscopy images is critical for training deep learning models in label-scarce environments, such as cell counting with many cells per image. However, traditional domain adaptation methods often struggle to bridge the domain gap when synthetic images lack the complex textures and visual patterns of real samples. In this work, we adapt the Inversion-Based Style Transfer (InST) framework originally designed for artistic style transfer to biomedical microscopy images. Our method combines latent-space Adaptive Instance Normalization with stochastic inversion in a diffusion model to transfer the style from real fuorescence microscopy images to synthetic ones, while weakly preserving content structure. We evaluate the effectiveness of our InST-based synthetic dataset for downstream cell counting by pre-training and fne tuning EffcientNet-B0 models on various data sources, including real data, hard-coded synthetic data, and the public Cell200-s dataset. Models trained with our InST-synthesized images achieve up to 37% lower Mean Absolute Error (MAE) compared to models trained on hard-coded synthetic data, and a 52% reduction in MAE compared to models trained on Cell200-s (from 53.70 to 25.95 MAE). Notably, our approach also outperforms models trained on real data alone (25.95 vs. 27.74 MAE). Further improvements are achieved when combining InST-synthesized data with lightweight domain adaptation techniques such as DACS with CutMix. These findings demonstrate that InST-based style transfer most effectively reduces the domain gap between synthetic and real microscopy data. Our approach offers a scalable path for enhancing cell counting performance while minimizing manual labeling effort. The source code and resources are publicly available at: https://github.com/MohammadDehghan/ InST-Microscopy
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- Award ID(s):
- 2152117
- PAR ID:
- 10678707
- Publisher / Repository:
- IEEE
- Date Published:
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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