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  1. ; ; ( , Downloaded 9 times Geo-Congress 2022)
    Free, publicly-accessible full text available March 7, 2023
  2. ; ; ; ( , Geosciences)
    Subsurface drainage has been widely accepted to mitigate the hazard of landslides in areas prone to flooding. Specifically, the use of drainage wells with pumping systems has been recognized as an effective short-term solution to lower the groundwater table. However, this method has not been well considered for long-term purposes due to potentially high labor costs. This study aims to investigate the idea of an autonomous pumping system for subsurface drainage by leveraging conventional geotechnical engineering solutions and a deep learning technique—Long-Short Term Memory (LSTM)—to establish a geotechnical cyber-physical system for rainfall-induced landslide prevention. For this purpose, a typical soilmore »slope equipped with three pumps was considered in a computer simulation. Forty-eight cases of rainfall events with a wide range of varieties in duration, total rainfall depths, and different rainfall patterns were generated. For each rainfall event, transient seepage analysis was performed using newly proposed Python code to obtain the corresponding pump’s flow rate data. A policy of water pumping for maintaining groundwater at a desired level was assigned to the pumps to generate the data. The LSTM takes rainfall event data as the input and predicts the required pump’s flow rate. The results from the trained model were validated using evaluation metrics of root mean square error (RMSE), mean absolute error (MAE), and R2. The R2-scores of 0.958, 0.962, and 0.954 for the predicted flow rates of the three pumps exhibited high accuracy of the predictions using the trained LSTM model. This study is intended to make a pioneering step toward reaching an autonomous pumping system and lowering the operational costs in controlling geosystems.« less
    Free, publicly-accessible full text available February 1, 2023
  3. ; ; ; ( , Geotechnical and Geological Engineering)
    Free, publicly-accessible full text available February 1, 2023
  4. ; ( , The Journal of Chemical Physics)
    Free, publicly-accessible full text available December 7, 2022
  5. ; ; ( , Acta Geotechnica)
    Free, publicly-accessible full text available October 1, 2022
  6. ; ; ; ; ( , 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC))
    Free, publicly-accessible full text available November 1, 2022
  7. ; ; ; ; ; ; ; ; ( , Journal of the American Chemical Society)
    Propargyl amines are versatile synthetic intermediates with numerous applications in the pharmaceutical industry. An attractive strategy for efficient preparation of these compounds is nitrene propargylic C(sp3)−H insertion. However, achieving this reaction with good chemo-, regio-, and enantioselective control has proven to be challenging. Here, we report an enzymatic platform for the enantioselective propargylic amination of alkynes using a hydroxylamine derivative as the nitrene precursor. Cytochrome P450 variant PA-G8 catalyzing this transformation was identified after eight rounds of directed evolution. A variety of 1-aryl-2-alkyl alkynes are accepted by PA G8, including those bearing heteroaromatic rings. This biocatalytic process is efficient andmore »selective (up to 2610 total turnover number (TTN) and 96% ee) and can be performed on preparative scale.« less
    Free, publicly-accessible full text available December 23, 2022
  8. ; ; ; ; ; ( , Nature Chemistry)
    Chiral amines can be made by insertion of a carbene into an N–H bond using two-catalyst systems that combine a transition metal-based carbene-transfer catalyst and a chiral proton-transfer catalyst to enforce stereocontrol. Haem proteins can effect carbene N–H insertion, but asymmetric protonation in an active site replete with proton sources is challenging. Here we describe engineered cytochrome P450 enzymes that catalyse carbene N–H insertion to prepare biologically relevant α-amino lactones with high activity and enantioselectivity (up to 32,100 total turnovers, >99% yield and 98% e.e.). These enzymes serve as dual-function catalysts, inducing carbene transfer and promoting the subsequent proton transfer withmore »excellent stereoselectivity in a single active site. Computational studies uncover the detailed mechanism of this new-to-nature enzymatic reaction and explain how active-site residues accelerate this transformation and provide stereocontrol.« less
    Free, publicly-accessible full text available October 18, 2022
  9. ; ; ( , European Journal of Pharmaceutics and Biopharmaceutics)
    Full Text Available 
  10. ; ( , Current Opinion in Biotechnology)
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