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The current work studies the correlations between microstructure and retained austenite (RA) transformation, in a single-quenched and partitioned (Q&P) 1180 steel microstructure, through in situ tensile tests combined with electron backscatter diffraction (EBSD) analysis. This allows the study of RA stability across a limited range of morphological characteristics to be studied in the absence of confounding factors introduced by varying the entire steel microstructure. Among the microstructural attributes of interest, RA grain aspect ratio is found to have the largest influence on transformation rate, where globular-shaped grains transform more slowly than those with a more lenticular shape. Furthermore, by tracking individual grains during deformation, it is apparent that larger grains transformed more slowly than smaller grains; a purely statistical study of grain size vs strain might conclude that smaller grains are more stable, but in reality, the smaller grains transform faster and are simply statistically replaced by partially transformed larger grains. These conclusions are in contrast to relationships that might be inferred from previous studies where the entire steel microstructure was varied, along with the morphology of the RA. 

Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate mammalian tissue age with high accuracy (r > 0.96). Age deviations correlate with human mortality risk, mouse somatotropic axis mutations and caloric restriction. We identified specific cytosines with methylation levels that change with age across numerous species. These sites, highly enriched in polycomb repressive complex 2-binding locations, are near genes implicated in mammalian development, cancer, obesity and longevity. Our findings offer new evidence suggesting that aging is evolutionarily conserved and intertwined with developmental processes across all mammals.

 

The Cryogenic Underground Observatory for Rare Events (CUORE) is the first cryogenic experiment searching for$$0\nu \beta \beta $$$0\nu \beta \beta$decay that has been able to reach the one-tonne mass scale. The detector, located at the Laboratori Nazionali del Gran Sasso (LNGS) in Italy, consists of an array of 988$${\mathrm{TeO}}_{2}$$${\mathrm{TeO}}_2$crystals arranged in a compact cylindrical structure of 19 towers. CUORE began its first physics data run in 2017 at a base temperature of about 10 mK and in April 2021 released its$$3{\mathrm{rd}}$$$3\mathrm{rd}$result of the search for$$0\nu \beta \beta $$$0\nu \beta \beta$, corresponding to a tonne-year of$$\mathrm{TeO}_{2}$$${\mathrm{TeO}}_2$exposure. This is the largest amount of data ever acquired with a solid state detector and the most sensitive measurement of$$0\nu \beta \beta $$$0\nu \beta \beta$decay in$${}^{130}\mathrm{Te}$$${}^{130}\mathrm{Te}$ever conducted . We present the current status of CUORE search for$$0\nu \beta \beta $$$0\nu \beta \beta$with the updated statistics of one tonne-yr. We finally give an update of the CUORE background model and the measurement of the$${}^{130}\mathrm{Te}$$${}^{130}\mathrm{Te}$$$2\nu \beta \beta $$$2\nu \beta \beta$decay half-life and decay to excited states of$${}^{130}\mathrm{Xe}$$${}^{130}\mathrm{Xe}$, studies performed using an exposure of 300.7 kg yr.

 

Abstract The possibility that neutrinos may be their own antiparticles, unique among the known fundamental particles, arises from the symmetric theory of fermions proposed by Ettore Majorana in 1937 1 . Given the profound consequences of such Majorana neutrinos, among which is a potential explanation for the matter–antimatter asymmetry of the universe via leptogenesis 2 , the Majorana nature of neutrinos commands intense experimental scrutiny globally; one of the primary experimental probes is neutrinoless double beta (0 νββ ) decay. Here we show results from the search for 0 νββ decay of 130 Te, using the latest advanced cryogenic calorimeters with the CUORE experiment 3 . CUORE, operating just 10 millikelvin above absolute zero, has pushed the state of the art on three frontiers: the sheer mass held at such ultralow temperatures, operational longevity, and the low levels of ionizing radiation emanating from the cryogenic infrastructure. We find no evidence for 0 νββ decay and set a lower bound of the process half-life as 2.2 × 10 25  years at a 90 per cent credibility interval. We discuss potential applications of the advances made with CUORE to other fields such as direct dark matter, neutrino and nuclear physics searches and large-scale quantum computing, which can benefit from sustained operation of large payloads in a low-radioactivity, ultralow-temperature cryogenic environment. 

Abstract The CUORE experiment is a large bolometric array searching for the lepton number violating neutrino-less double beta decay ( $$0\nu \beta \beta $$ 0 ν β β ) in the isotope $$\mathrm {^{130}Te}$$ 130 Te . In this work we present the latest results on two searches for the double beta decay (DBD) of $$\mathrm {^{130}Te}$$ 130 Te to the first $$0^{+}_2$$ 0 2 + excited state of $$\mathrm {^{130}Xe}$$ 130 Xe : the $$0\nu \beta \beta $$ 0 ν β β decay and the Standard Model-allowed two-neutrinos double beta decay ( $$2\nu \beta \beta $$ 2 ν β β ). Both searches are based on a 372.5 kg $$\times $$ × yr TeO $$_2$$ 2 exposure. The de-excitation gamma rays emitted by the excited Xe nucleus in the final state yield a unique signature, which can be searched for with low background by studying coincident events in two or more bolometers. The closely packed arrangement of the CUORE crystals constitutes a significant advantage in this regard. The median limit setting sensitivities at 90% Credible Interval (C.I.) of the given searches were estimated as $$\mathrm {S^{0\nu }_{1/2} = 5.6 \times 10^{24} \, \mathrm {yr}}$$ S 1 / 2 0 ν = 5.6 × 10 24 yr for the $${0\nu \beta \beta }$$ 0 ν β β decay and $$\mathrm {S^{2\nu }_{1/2} = 2.1 \times 10^{24} \, \mathrm {yr}}$$ S 1 / 2 2 ν = 2.1 × 10 24 yr for the $${2\nu \beta \beta }$$ 2 ν β β decay. No significant evidence for either of the decay modes was observed and a Bayesian lower bound at $$90\%$$ 90 % C.I. on the decay half lives is obtained as: $$\mathrm {(T_{1/2})^{0\nu }_{0^+_2} > 5.9 \times 10^{24} \, \mathrm {yr}}$$ ( T 1 / 2 ) 0 2 + 0 ν > 5.9 × 10 24 yr for the $$0\nu \beta \beta $$ 0 ν β β mode and $$\mathrm {(T_{1/2})^{2\nu }_{0^+_2} > 1.3 \times 10^{24} \, \mathrm {yr}}$$ ( T 1 / 2 ) 0 2 + 2 ν > 1.3 × 10 24 yr for the $$2\nu \beta \beta $$ 2 ν β β mode. These represent the most stringent limits on the DBD of $$^{130}$$ 130 Te to excited states and improve by a factor $$\sim 5$$ ∼ 5 the previous results on this process.