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Abstract Polyvinylpyrrolidone (PVP) fibers embedded with Zinc Oxide nanoparticles (ZnO NPs) were prepared by the centrifugal spinning of aqueous PVP solutions and ZnO NPs. The ZnO NPs were synthesized and coated with either cetyltrimethylammonium bromide or hexadecyltrimethylammonium bromide. The structure and morphology of the nanocomposite fibers were studied using scanning electron microscopy, X‐ray diffraction, energy‐dispersive X‐ray spectroscopy, Fourier transformed infrared spectroscopy and Thermogravimetric analysis. The effect of surfactant coating on the antibacterial activity of ZnO NPs and PVP/ZnO nanocomposite fibers againstEscherichia coli(E. coli) andBacillus megaterium(B. megaterium) bacteria was systematically investigated. The present study indicated that coating the ZnO NPs with surfactants resulted in large and uniform inhibition of bacterial growth.
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Matrix-Assisted Pulsed laser Evaporation-deposited Rapamycin Thin Films Maintain Antiproliferative Activity
Matrix-assisted pulsed laser evaporation (MAPLE) has many benefits over conventional methods (e.g., dip-coating, spin coating, and Langmuir–Blodgett dip-coating) for manufacturing coatings containing pharmacologic agents on medical devices. In particular, the thickness of the coating that is applied to the surface of the medical device can be tightly controlled. In this study, MAPLE was used to deposit rapamycin-polyvinylpyrrolidone (rapamycin-PVP) thin films onto silicon and borosilicate optical glass substrates. Alamar Blue and PicoGreen studies were used to measure the metabolic health and DNA content of L929 mouse fibroblasts as measures of viability and proliferation, respectively. The cells on the MAPLE-deposited rapamycin-PVP surfaces exhibited 70.6% viability and 53.7% proliferation compared to a borosilicate glass control. These data indicate that the antiproliferative properties of rapamycin were maintained after MAPLE deposition.
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- Award ID(s):
- 1762202
- PAR ID:
- 10143190
- Date Published:
- Journal Name:
- International Journal of Bioprinting
- Volume:
- 6
- Issue:
- 1
- ISSN:
- 2424-7723
- Page Range / eLocation ID:
- 105; 111
- Format(s):
- Medium: X
- Sponsoring Org:
- National Science Foundation
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- Free Publicly Accessible Full Text
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Accepted Manuscript1.0
- Journal Article:
- https://doi.org/10.18063/ijb.v6i1.188
