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This qualitative study examined the college pathways of mostly working-class immigrant-origin youth of color (Black, East Asian, Latino/a) in New York City. Using a thematic analysis approach with bridging multiple worlds theory and social capital theory as guiding conceptual frameworks, we examined facilitators and barriers that 30 working-class immigrant-origin youth of color encountered in different worlds (family, school, peers, and community programs) in their college pathways. Our analysis found that most students received emotional but not instrumental support from their parents, notably that their parents mainly wanted them to be happy and to pursue a college degree that would lead to non-blue-collar work. Students received emotional and instrumental guidance from school staff, and many students received help from, and in return helped, their peers. Students who had access to community programs and external resources found them to be helpful in receiving feedback on college application materials and perspectives about different career paths. Students also noted barriers, including family circumstances and immigration status, that hindered their college pathways. We discuss similarities and differences in facilitators and barriers that different racial groups experienced, as well as contributions to literature and implications for removing barriers for immigrant-origin youth of color. (PsycInfo Database Record (c) 2024 APA, all rights reserved) 

The anisotropy of energetic particles provides essential information to help resolve the underlying fundamental physics of their spatial distributions, injection, acceleration, and transport processes. In this work, we report an energetic ion enhancement that is characterized by very large and long-lasting anisotropies observed by STEREO A and Solar Orbiter, which are nearly aligned along the same nominal Parker spiral. This ion enhancement appears at the rising phase of a widespread solar energetic particle event that was associated with the farside coronal mass ejection on 2022 February 15. According to our analysis, the long-lasting anisotropy resulted from the continuous injection of energetic ions from a well-connected particle source located beyond the STEREO A’s orbit. Solar Orbiter also observed an interval of very large anisotropy dominated exclusively by sunward streaming ions but with the additional implication that it detected the very early phase of ion injections onto magnetic field lines that newly connected to the particle source, which is likely the first reported event of this kind. These results further illustrate how energetic particle anisotropy information, in particular from multiple observer locations, can be used to disentangle the sources and transport processes of energetic ions, even when their heliospheric context is not simple.

 

We propose a generalization of the synthetic controls and synthetic interventions methodology to incorporate network interference. We consider the estimation of unit-specific potential outcomes from panel data in the presence of spillover across units and unobserved confounding. Key to our approach is a novel latent factor model that takes into account network interference and generalizes the factor models typically used in panel data settings. We propose an estimator, Network Synthetic Interventions (NSI), and show that it consistently estimates the mean outcomes for a unit under an arbitrary set of counterfactual treatments for the network. We further establish that the estimator is asymptotically normal. We furnish two validity tests for whether the NSI estimator reliably generalizes to produce accurate counterfactual estimates. We provide a novel graph-based experiment design that guarantees the NSI estimator produces accurate counterfactual estimates, and also analyze the sample complexity of the proposed design. We conclude with simulations that corroborate our theoretical findings. 

On 2022 February 15, an impressive filament eruption was observed off the solar eastern limb from three remote-sensing viewpoints, namely, Earth, STEREO-A, and Solar Orbiter. In addition to representing the most-distant observed filament at extreme ultraviolet wavelengths—captured by Solar Orbiter's field of view extending to above 6R_⊙—this event was also associated with the release of a fast (∼2200 km s⁻¹) coronal mass ejection (CME) that was directed toward BepiColombo and Parker Solar Probe. These two probes were separated by 2° in latitude, 4° in longitude, and 0.03 au in radial distance around the time of the CME-driven shock arrival in situ. The relative proximity of the two probes to each other and the Sun (∼0.35 au) allows us to study the mesoscale structure of CMEs at Mercury's orbit for the first time. We analyze similarities and differences in the main CME-related structures measured at the two locations, namely, the interplanetary shock, the sheath region, and the magnetic ejecta. We find that, despite the separation between the two spacecraft being well within the typical uncertainties associated with determination of CME geometric parameters from remote-sensing observations, the two sets of in situ measurements display some profound differences that make understanding the overall 3D CME structure particularly challenging. Finally, we discuss our findings within the context of space weather at Mercury's distance and in terms of the need to investigate solar transients via spacecraft constellations with small separations, which has been gaining significant attention during recent years.

 

Objective.Extracting signals directly from the motor system poses challenges in obtaining both high amplitude and sustainable signals for upper-limb neuroprosthetic control. To translate neural interfaces into the clinical space, these interfaces must provide consistent signals and prosthetic performance.Approach.Previously, we have demonstrated that the Regenerative Peripheral Nerve Interface (RPNI) is a biologically stable, bioamplifier of efferent motor action potentials. Here, we assessed the signal reliability from electrodes surgically implanted in RPNIs and residual innervated muscles in humans for long-term prosthetic control.Main results.RPNI signal quality, measured as signal-to-noise ratio, remained greater than 15 for up to 276 and 1054 d in participant 1 (P1), and participant 2 (P2), respectively. Electromyography from both RPNIs and residual muscles was used to decode finger and grasp movements. Though signal amplitude varied between sessions, P2 maintained real-time prosthetic performance above 94% accuracy for 604 d without recalibration. Additionally, P2 completed a real-world multi-sequence coffee task with 99% accuracy for 611 d without recalibration.Significance.This study demonstrates the potential of RPNIs and implanted EMG electrodes as a long-term interface for enhanced prosthetic control.

 

This perspective article discusses the knowledge gaps and open questions regarding the solar and interplanetary drivers of space weather conditions experienced at Mars during active and quiescent solar periods, and the need for continuous, routine observations to address them. For both advancing science and as part of the strategic planning for human exploration at Mars by the late 2030s, now is the time to consider a network of upstream space weather monitors at Mars. Our main recommendations for the heliophysics community are the following: 1. Support the advancement for understanding heliophysics and space weather science at ∼1.5 AU and continue the support of planetary science payloads and missions that provide such measurements. 2. Prioritize an upstream Mars L1 monitor and/or areostationary orbiters for providing dedicated, continuous observations of solar activity and interplanetary conditions at ∼1.5 AU. 3. Establish new or support existing 1) joint efforts between federal agencies and their divisions and 2) international collaborations to carry out #1 and #2. 

This perspective paper brings to light the need for comprehensive studies on the evolution of interplanetary coronal mass ejection (ICME) complexity during propagation. To date, few studies of ICME complexity exist. Here, we define ICME complexity and associated changes in complexity, describe recent works and their limitations, and outline key science questions that need to be tackled. Fundamental research on ICME complexity changes from the solar corona to 1 AU and beyond is critical to our physical understanding of the evolution and interaction of transients in the inner heliosphere. Furthermore, a comprehensive understanding of such changes is required to understand the space weather impact of ICMEs at different heliospheric locations and to improve on predictive space weather models. 

Stealth coronal mass ejections (CMEs) are eruptions from the Sun that are not associated with appreciable low-coronal signatures. Because they often cannot be linked to a well-defined source region on the Sun, analysis of their initial magnetic configuration and eruption dynamics is particularly problematic. In this article, we address this issue by undertaking the first attempt at predicting the magnetic fields of a stealth CME that erupted in 2020 June from the Earth-facing Sun. We estimate its source region with the aid of off-limb observations from a secondary viewpoint and photospheric magnetic field extrapolations. We then employ the Open Solar Physics Rapid Ensemble Information modeling suite to evaluate its early evolution and forward model its magnetic fields up to Parker Solar Probe, which detected the CME in situ at a heliocentric distance of 0.5 au. We compare our hindcast prediction with in situ measurements and a set of flux-rope reconstructions, obtaining encouraging agreement on arrival time, spacecraft-crossing location, and magnetic field profiles. This work represents a first step toward reliable understanding and forecasting of the magnetic configuration of stealth CMEs and slow streamer-blowout events.

 

Breast and mammary epithelial cells experience different local environments during tissue development and tumorigenesis. Microenvironmental heterogeneity gives rise to distinct cell regulatory states whose identity and importance are just beginning to be appreciated. Cellular states diversify when clonal three-dimensional (3D) spheroids are cultured in basement membrane, and one such state is associated with stress tolerance and poor response to anticancer therapeutics. Here, we found that this state was jointly coordinated by the NRF2 and p53 pathways, which were costabilized by spontaneous oxidative stress within 3D cultures. Inhibition of NRF2 or p53 individually disrupted some of the transcripts defining the regulatory state but did not yield a notable phenotype in nontransformed breast epithelial cells. In contrast, combined perturbation prevented 3D growth in an oxidative stress–dependent manner. By integrating systems models of NRF2 and p53 signaling in a single oxidative stress network, we recapitulated these observations and made predictions about oxidative stress profiles during 3D growth. NRF2 and p53 signaling were similarly coordinated in normal breast epithelial tissue and hormone-negative ductal carcinoma in situ lesions but were uncoupled in triple-negative breast cancer (TNBC), a subtype in which p53 is usually mutated. Using the integrated model, we correlated the extent of this uncoupling in TNBC cell lines with the importance of NRF2 in the 3D growth of these cell lines and their predicted handling of oxidative stress. Our results point to an oxidative stress tolerance network that is important for single cells during glandular development and the early stages of breast cancer.