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Over the last two decades, there has been a growth in the applications of geographically-explicit agent-based models. One thing such models have in common is the creation of synthetic populations to initialize the artificial worlds in which the agents inhabit. One challenge such models face is that it is often difficult to create reusable geographically-explicit synthetic populations with social networks. In this paper, we introduce a Python based method that generates a reusable geographically-explicit synthetic population dataset along with its social networks. In addition, we present a pipeline for using the population datasets for model initialization. With this pipeline, multiple spatial and temporal scales of geographically-explicit agent-based models are presented focusing on Western New York. Such models not only demonstrate the utility of our synthetic population on commuting patterns but also how social networks can impact the simulation of disease spread and vaccination uptake. By doing so, this pipeline could benefit any modeler wishing to reuse synthetic populations with realistic geographic locations and social networks.