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Abstract We present the full Hubble diagram of photometrically classified Type Ia supernovae (SNe Ia) from the Dark Energy Survey supernova program (DES-SN). DES-SN discovered more than 20,000 SN candidates and obtained spectroscopic redshifts of 7000 host galaxies. Based on the light-curve quality, we select 1635 photometrically identified SNe Ia with spectroscopic redshift 0.10 <z< 1.13, which is the largest sample of supernovae from any single survey and increases the number of knownz> 0.5 supernovae by a factor of 5. In a companion paper, we present cosmological results of the DES-SN sample combined with 194 spectroscopically classified SNe Ia at low redshift as an anchor for cosmological fits. Here we present extensive modeling of this combined sample and validate the entire analysis pipeline used to derive distances. We show that the statistical and systematic uncertainties on cosmological parameters are ${\sigma }_{{\mathrm{\Omega }}_M,\mathrm{stat}+\mathrm{sys}}^{\mathrm{\Lambda }\mathrm{CDM}}=$0.017 in a flat ΛCDM model, and $({\sigma }_{{\mathrm{\Omega }}_M},{\sigma }_w{)}_{\mathrm{stat}+\mathrm{sys}}^{w\mathrm{CDM}}$= (0.082, 0.152) in a flatwCDM model. Combining the DES SN data with the highly complementary cosmic microwave background measurements by Planck Collaboration reduces by a factor of 4 uncertainties on cosmological parameters. In all cases, statistical uncertainties dominate over systematics. We show that uncertainties due to photometric classification make up less than 10% of the total systematic uncertainty budget. This result sets the stage for the next generation of SN cosmology surveys such as the Vera C. Rubin Observatory's Legacy Survey of Space and Time. 

Abstract We presentgrizphotometric light curves for the full 5 yr of the Dark Energy Survey Supernova (DES-SN) program, obtained with both forced point-spread function photometry on difference images (DiffImg) performed during survey operations, and scene modelling photometry (SMP) on search images processed after the survey. This release contains 31,636DiffImgand 19,706 high-quality SMP light curves, the latter of which contain 1635 photometrically classified SNe that pass cosmology quality cuts. This sample spans the largest redshift (z) range ever covered by a single SN survey (0.1 <z< 1.13) and is the largest single sample from a single instrument of SNe ever used for cosmological constraints. We describe in detail the improvements made to obtain the final DES-SN photometry and provide a comparison to what was used in the 3 yr DES-SN spectroscopically confirmed Type Ia SN sample. We also include a comparative analysis of the performance of the SMP photometry with respect to the real-timeDiffImgforced photometry and find that SMP photometry is more precise, more accurate, and less sensitive to the host-galaxy surface brightness anomaly. The public release of the light curves and ancillary data can be found atgithub.com/des-science/DES-SN5YRand doi:10.5281/zenodo.12720777. 

Temporal correlation in dynamic magnetic resonance imaging (MRI), such as cardiac MRI, is in- formative and important to understand motion mechanisms of body regions. Modeling such in- formation into the MRI reconstruction process produces temporally coherent image sequence and reduces imaging artifacts and blurring. However, existing deep learning based approaches neglect motion information during the reconstruction procedure, while traditional motion-guided methods are hindered by heuristic parameter tuning and long inference time. We propose a novel dynamic MRI reconstruction approach called MODRN that unitizes deep neural networks with motion in- formation to improve reconstruction quality. The central idea is to decompose the motion-guided optimization problem of dynamic MRI reconstruction into three components: dynamic reconstruc- tion, motion estimation and motion compensation. Extensive experiments have demonstrated the effectiveness of our proposed approach compared to other state-of-the-art approaches. 

Existing neural cell tracking methods generally use the morphology cell features for data association. However, these features are limited to the quality of cell segmentation and are prone to errors for mitosis determination. To over- come these issues, in this work we propose an online multi- object tracking method that leverages both cell appearance and motion features for data association. In particular, we propose a supervised blob-seed network (BSNet) to predict the cell appearance features and an unsupervised optical flow network (UnFlowNet) for capturing the cell motions. The data association is then solved using the Hungarian al- gorithm. Experimental evaluation shows that our approach achieves better performance than existing neural cell track- ing methods. 

We consider an MRI reconstruction problem with input of k-space data at a very low undersampled rate. This can prac- tically benefit patient due to reduced time of MRI scan, but it is also challenging since quality of reconstruction may be compromised. Currently, deep learning based methods dom- inate MRI reconstruction over traditional approaches such as Compressed Sensing, but they rarely show satisfactory performance in the case of low undersampled k-space data. One explanation is that these methods treat channel-wise fea- tures equally, which results in degraded representation ability of the neural network. To solve this problem, we propose a new model called MRI Cascaded Channel-wise Attention Network (MICCAN), highlighted by three components: (i) a variant of U-net with Channel-wise Attention (UCA) mod- ule, (ii) a long skip connection and (iii) a combined loss. Our model is able to attend to salient information by filtering irrelevant features and also concentrate on high-frequency in- formation by enforcing low-frequency information bypassed to the final output. We conduct both quantitative evaluation and qualitative analysis of our method on a cardiac dataset. The experiment shows that our method achieves very promis- ing results in terms of three common metrics on the MRI reconstruction with low undersampled k-space data. Code is public available 

Nuclei segmentation is a fundamental task in histopathological image analysis. Typically, such segmentation tasks require significant effort to manually generate pixel-wise annotations for fully supervised training. To alleviate the manual effort, in this paper we propose a novel approach using points only annotation. Two types of coarse labels with complementary information are derived from the points annotation, and are then utilized to train a deep neural network. The fully- connected conditional random field loss is utilized to further refine the model without introducing extra computational complexity during inference. Experimental results on two nuclei segmentation datasets reveal that the proposed method is able to achieve competitive performance compared to the fully supervised counterpart and the state-of-the-art methods while requiring significantly less annotation effort. Our code is publicly available. 

Abstract Redshift measurements, primarily obtained from host galaxies, are essential for inferring cosmological parameters from type Ia supernovae (SNe Ia). Matching SNe to host galaxies using images is nontrivial, resulting in a subset of SNe with mismatched hosts and thus incorrect redshifts. We evaluate the host galaxy mismatch rate and resulting biases on cosmological parameters from simulations modeled after the Dark Energy Survey 5 Yr (DES-SN5YR) photometric sample. For both DES-SN5YR data and simulations, we employ the directional light radius method for host galaxy matching. In our SN Ia simulations, we find that 1.7% of SNe are matched to the wrong host galaxy, with redshift differences between the true and matched hosts of up to 0.6. Using our analysis pipeline, we determine the shift in the dark energy equation of state parameter (Δw) due to including SNe with incorrect host galaxy matches. For SN Ia–only simulations, we find Δw= 0.0013 ± 0.0026 with constraints from the cosmic microwave background. Including core-collapse SNe and peculiar SNe Ia in the simulation, we find that Δwranges from 0.0009 to 0.0032, depending on the photometric classifier used. This bias is an order of magnitude smaller than the expected total uncertainty onwfrom the DES-SN5YR sample of ∼0.03. We conclude that the bias onwfrom host galaxy mismatch is much smaller than the uncertainties expected from the DES-SN5YR sample, but we encourage further studies to reduce this bias through better host-matching algorithms or selection cuts. 

Neural cell instance segmentation serves as a valuable tool for the study of neural cell behaviors. In general, the instance segmentation methods compute the region of interest (ROI) through a detection module, where the segmentation is sub- sequently performed. To precisely segment the neural cells, especially their tiny and slender structures, existing work em- ploys a u-net structure to preserve the low-level details and encode the high-level semantics. However, such method is insufficient for differentiating the adjacent cells when large parts of them are included in the same cropped ROI. To solve this problem, we propose a context-refined neural cell instance segmentation model that learns to suppress the back- ground information. In particular, we employ a light-weight context refinement module to recalibrate the deep features and focus the model exclusively on the target cell within each cropped ROI. The proposed model is efficient and accurate, and experimental results demonstrate its superiority com- pared to the state-of-the-arts. 

Nuclei segmentation and classification are two important tasks in the histopathology image analysis, because the mor- phological features of nuclei and spatial distributions of dif- ferent types of nuclei are highly related to cancer diagnosis and prognosis. Existing methods handle the two problems independently, which are not able to obtain the features and spatial heterogeneity of different types of nuclei at the same time. In this paper, we propose a novel deep learning based method which solves both tasks in a unified framework. It can segment individual nuclei and classify them into tumor, lymphocyte and stroma nuclei. Perceptual loss is utilized to enhance the segmentation of details. We also take advantages of transfer learning to promote the training of deep neural net- works on a relatively small lung cancer dataset. Experimental results prove the effectiveness of the proposed method. The code is publicly available 

Abstract We present cosmological constraints from the sample of Type Ia supernovae (SNe Ia) discovered and measured during the full 5 yr of the Dark Energy Survey (DES) SN program. In contrast to most previous cosmological samples, in which SNe are classified based on their spectra, we classify the DES SNe using a machine learning algorithm applied to their light curves in four photometric bands. Spectroscopic redshifts are acquired from a dedicated follow-up survey of the host galaxies. After accounting for the likelihood of each SN being an SN Ia, we find 1635 DES SNe in the redshift range 0.10 <z< 1.13 that pass quality selection criteria sufficient to constrain cosmological parameters. This quintuples the number of high-qualityz> 0.5 SNe compared to the previous leading compilation of Pantheon+ and results in the tightest cosmological constraints achieved by any SN data set to date. To derive cosmological constraints, we combine the DES SN data with a high-quality external low-redshift sample consisting of 194 SNe Ia spanning 0.025 <z< 0.10. Using SN data alone and including systematic uncertainties, we find Ω_M= 0.352 ± 0.017 in flat ΛCDM. SN data alone now require acceleration (q₀< 0 in ΛCDM) with over 5σconfidence. We find $({\mathrm{\Omega }}_{\mathrm{M}},w)=({0.264}_{-0.096}^{+0.074},-{0.80}_{-0.16}^{+0.14})$in flatwCDM. For flatw₀w_aCDM, we find $({\mathrm{\Omega }}_{\mathrm{M}},w_0,w_a)=({0.495}_{-0.043}^{+0.033},-{0.36}_{-0.30}^{+0.36},-{8.8}_{-4.5}^{+3.7})$, consistent with a constant equation of state to within ∼2σ. Including Planck cosmic microwave background, Sloan Digital Sky Survey baryon acoustic oscillation, and DES 3 × 2pt data gives (Ω_M,w) = (0.321 ± 0.007, −0.941 ± 0.026). In all cases, dark energy is consistent with a cosmological constant to within ∼2σ. Systematic errors on cosmological parameters are subdominant compared to statistical errors; these results thus pave the way for future photometrically classified SN analyses.